Heparin sodium Cas: 9041-08-1 ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, hygroscopic ntụ ntụ
| Nọmba katalọgụ | XD90184 |
| Aha ngwaahịa | Heparin sodium |
| CAS | 9041-08-1 |
| Usoro ihe omimi | C12H17NO20S3 |
| Ibu molekụla | 591.45 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 30019091 |
Nkọwapụta ngwaahịa
| Ọdịdị | ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, hygroscopic ntụ ntụ |
| Asay | 99% |
| Ntughari pụrụ iche | Ngwaahịa akọrọ ekwesịghị ịbụ ihe na-erughị +50 Celsius |
| pH | 5.5-8.0 |
| Ọgwụ nje endotoxin | Ihe na-erughị 0.01 IU kwa International Unit nke heparin |
| Ihe mgbaze fọdụrụnụ | Dabere na usoro ọkọlọtọ nke ime ya na ngụkọta mpaghara kacha elu, methanol, ethanol, acetone, na, n'aka nke ya, 0.3%, 0.5%, ma ọ bụ ihe na-erughị ya. |
| Ihe fọdụrụ na mgbanye | 28.0% -41.0% |
| Sodium | 10.5% -13.5% (ihe akpọnwụwo) |
| Protein | <0.5% (ihe akpọnwụwo) |
| Nitrogen | 1.3% -2.5% (ihe akpọnwụwo) |
| Nucleotidic adịghị ọcha | 260nm <0.10 |
| Ọla dị arọ | ≤30pm |
| O doro anya na agba nke ngwọta | Ngwọta kwesịrị ịdị ọcha enweghị agba;Dị ka turbidity, ultraviolet-visible spectrophotometry, mkpebi nke absorbance na wavelength nke 640 nm, agaghị agafe 0.018;Dị ka agba, tụnyere ọkọlọtọ colorimetric mmiri mmiri edo edo, agaghị adị omimi |
| Ihe metụtara | Nchikota nke dermatan sulfate na chondroitin sulfate: ọ bụghị karịa ikuku nke ọnụ ọgụgụ kacha elu kwekọrọ na chomatogram nwetara site na ngwọta ntụaka.Ọdịghị ọcha ọ bụla ọzọ: ọ dịghị elu karịa elu n'ihi determatan sulfate na chondroitin sulfate na-achọpụta. |
| mgbochi FXa / mgbochi FIIa | 0.9-1.1 |
| chromatography nke mmiri mmiri | Ngwọta nlele njikwa na chromatogram, dermatan sulfate (oke elu na heparin na dermatan sulfate) n'etiti oke elu ndagwurugwu ekwesịghị ịbụ ihe na-erughị 1.3, nke enwetara na ngwọta nnwale yiri ya na oge njide na ọdịdị ya na chromatogram kachasị elu na chromatogram nwetara ya. ntụaka ngwọta.Ogologo oge ndowe agaghị aga 5% |
| Ibu arọ molecular na nkesa arọ molekụla | Ibu arọ molekụla dị arọ kwesịrị ịbụ 15000 - 19000. Ihe dị arọ nke ihe karịrị 24000 nke ọkwa agaghị adị elu karịa 20%, ịdị arọ molecular nke 8000 - 16000 nke ịdị arọ molecular nke 24000 - 16000 nke oke ekwesịghị ịbụ obere. karịa 1 |
| akọrọ arọ ọnwụ | ≤5.0% |
| Micro ntule | Ngụkọta ọnụ ikuku ikuku nwere ike ime: <10³cfu/g .Fungi/yist <10²cfu/g |
| mgbochi ihe IIa | ≥180 IU/mg |
Heparin, sodium nnu bụ heparin polima nke na-emepụta mmetụta anticoagulant ya bụ isi site na ịgbalite antithrombin.Nkwalite a na-ebute mgbanwe mgbanwe na ATIII ma na-enye ohere maka mgbanwe mgbanwe na akaghị saịtị ya.Heparin bụ glycosaminoglycan sulfated nke ukwuu mara maka igbochi mkpụkọ.Heparin, sodium nnu bụkwa onye na-arụ ọrụ RyR na ATIII.
Njirimara anụ ahụ na kemịkalụ: Heparin sodium na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ntụ ntụ, enweghị isi, hygroscopic, soluble na mmiri, enweghị ike ime na ihe mgbaze organic dị ka ethanol na acetone.Ọ nwere ụgwọ ọjọọ siri ike na ngwọta mmiri ma nwee ike ijikọta ya na ụfọdụ cations iji mepụta ogige molekụla.Ngwọta mmiri na-esikwu ike na pH 7.
Anticoagulant: Heparin sodium bụ anticoagulant, mucopolysaccharide, sodium nnu nke glucosamine sulfate ewepụtara na eriri afọ mucosa nke ezì, ehi na atụrụ, na zoro ezo site mast cell n'ime ahụ mmadụ.Na ndammana dị n'ime ọbara.Heparin sodium nwere ọrụ nke igbochi nchịkọta platelet na mbibi, na-egbochi ntụgharị nke fibrinogen n'ime fibrin monomer, na-egbochi mmepụta nke thromboplastin na iguzogide thromboplastin kpụrụ, na-egbochi ntụgharị nke prothrombin n'ime thrombin na antithrombin.Heparin sodium nwere ike igbu oge ma ọ bụ gbochie coagulation ọbara ma na vitro ma na vivo.Usoro ọrụ ya dị oke mgbagwoju anya ma na-emetụta ọtụtụ njikọ na usoro coagulation.Ọrụ ya bụ: ① igbochi nhazi na ọrụ nke thromboplastin, si otú a na-egbochi prothrombin ịghọ thrombin;② na mkpokọta dị elu, ọ nwere mmetụta nke igbochi thrombin na ihe ndị ọzọ na-akpata coagulation, na-egbochi fibrinogen ịghọ Protein fibrin;③ nwere ike igbochi mkpokọta na mbibi nke platelet.Na mgbakwunye, mmetụta anticoagulant nke heparin sodium ka na-ejikọta ya na radical sulfate na-adịghị mma na molecule ya.Ngwunye alkaline na-akwụ ụgwọ nke ọma dị ka protamine ma ọ bụ toluidine blue nwere ike wepụ ụgwọ ọjọọ ya, ya mere ọ nwere ike igbochi anticoagulation ya.mmetụta.N'ihi na heparin nwere ike ịgbalite ma hapụ lipoprotein lipase na vivo, hydrolyze triglyceride na lipoprotein dị obere nke chylomicrons, yabụ na ọ nwekwara mmetụta hypolipidemic.Enwere ike iji sodium heparin na-agwọ nnukwu ọrịa thromboembolic, na-ekesa coagulation intravascular (DIC).N'ime afọ ndị na-adịbeghị anya, achọpụtara heparin nwere mmetụta nke iwepụ lipids ọbara.Ngwunye ime n'ime nwa ma ọ bụ ntụtụ intramuscular miri emi (ma ọ bụ ntụtụ subcutaneous), nkeji 5,000 ruo 10,000 oge ọ bụla.Heparin sodium dị obere na-egbu egbu na ọbara ọgbụgba n'onwe ya bụ ihe ize ndụ kachasị mkpa nke ịṅụbiga mmanya ókè heparin.N'ọnụ na-adịghị arụ ọrụ, a ga-eji ntụtụ mee ya.Intramuscular injection or subcutaneous injections na-akpasu iwe karịa, mgbe ụfọdụ mmeghachi omume nfụkasị ahụ nwere ike ime, na ịṅụbiga mmanya ókè nwere ike ime ka njide obi;ntutu isi na-adịru nwa oge na afọ ọsịsa.Tụkwasị na nke ahụ, ọ ka nwere ike ịkpata mgbaji na mberede.Iji ogologo oge mee ihe nwere ike ịkpata thrombosis mgbe ụfọdụ, nke nwere ike ịbụ n'ihi nkwụsị nke anticoagulase-III.Heparin sodium bụ contraindicated na ndị ọrịa nwere ọbara ọgbụgba, oke imeju na akụrụ ezughi oke, ọbara mgbali elu siri ike, hemophilia, hemorrhage intracranial, ọnya peptic, ụmụ nwanyị dị ime na mgbe ịmụ nwa, etuto visceral, trauma na ịwa ahụ.
Na-eji: Nchọpụta biochemical, eji egbochi ntụgharị nke prothrombin n'ime thrombin, nwere mmetụta antithrombotic.
Na-eji: Heparin sodium bụ mucopolysaccharide biochemical ọgwụ ewepụtara na porcine eriri afọ mucosa nwere ike anticoagulant ọrụ.Mclcan chọtara heparin femoral mucopolysaccharide heparin n'ime anụ imeju site na nkịta mgbe ọ na-amụ usoro nke mkpụkọ ọbara.Brinkous et al.gosipụtara na heparin nwere ọrụ anticoagulant.Mgbe ejiri heparin mee ihe dị ka ọgwụ mgbochi na ngwa ụlọ ọgwụ maka oge mbụ, ọ natara nlebara anya site n'akụkụ nile nke ụwa.Ọ bụ ezie na ọ nwere akụkọ ihe mere eme nke ihe karịrị afọ 60 na-eji ụlọ ọgwụ eme ihe, ọ dịghị ngwaahịa ọ bụla nwere ike dochie ya kpamkpam, ya mere ọ ka bụ otu n'ime ọgwụ nje na-egbu egbu na antithrombotic kachasị mkpa.Ọ nwere ọtụtụ ihe eji eme ọgwụ.A na-eji ya na-agwọ nnukwu myocardial infarction na pathogenic ịba ọcha n'anya.Enwere ike iji ya jikọtara ya na ribonucleic acid iji mee ka ọrụ ịba ọcha n'anya B dịkwuo mma. Enwere ike iji ya na ọgwụgwọ chemotherapy iji gbochie thrombosis.Ọ nwere ike ibelata lipids ọbara ma melite ọrụ mgbochi mmadụ.nwekwara mmetụta ụfọdụ.Heparin sodium dị arọ dị ala nwere ọrụ anticoagulant factor Xa.Ọmụmụ ọgwụ ọgwụ egosila na heparin sodium dị ala dị ala nwere mmetụta mgbochi na nhazi nke thrombus na arteriovenous thrombosis na vivo na in vitro, mana ọ nwere obere mmetụta na coagulation na sistem fibrinolysis, na-ebute nsonaazụ antithrombotic.ọbara ọgbụgba na-adịkarị obere.Heparin na-adịghị emebi emebi bụ ngwakọta nke amino glucan glycosides dị iche iche nke nwere ike igbu oge ma ọ bụ gbochie coagulation ọbara ma na vitro ma na vivo.Usoro mgbochi ya dị mgbagwoju anya, ọ na-enwekwa mmetụta n'akụkụ niile nke coagulation.Gụnyere mgbochi nke prothrombin n'ime thrombin;mgbochi nke ọrụ thrombin;na-egbochi mgbanwe nke fibrinogen n'ime fibrin;gbochie nchịkọta platelet na mbibi.Heparin ka nwere ike belata lipids ọbara, na-ebelata LDL na VLDL, na-abawanye HDL, gbanwee viscosity ọbara, chebe mkpụrụ ndụ endothelial vaskụla, gbochie atherosclerosis, na-akwalite mgbasa ọbara, ma melite mgbasa ọbara.
Na-eji: Nnyocha biochemical, iji gbochie ngbanwe nke prothrombin n'ime thrombin.
Na-eji: A na-eji egbu oge ma gbochie mkpụkọ ọbara
