Ngwaahịa

Ọtụtụ guanosine analogues, ie acyclovir (na ọnụ prodrug valaciclovir), penciclovir (n'ụdị prodrug ya, famciclovir) na ganciclovir, na-ọtụtụ ebe maka ọgwụgwọ nke herpesvirus [ie herpes simplex virus ụdị 1 (HSV-1), na ụdị. 2 (HSV-2), nje varicella-zoster (VZV) na/ma ọ bụ cytomegalovirus mmadụ (HCMV)] na-efe efe.N'ime afọ ndị na-adịbeghị anya, e mepụtara ọtụtụ analogues guanosine ọhụrụ, gụnyere 3-membered cyclopropylmethyl na -methenyl derivatives (A-5021 na synguanol) na 6-membered D- na L-cyclohexenyl.Achọpụtala ọrụ nke acyclic / carbocyclic guanosine analogues megide ụdị nje dị iche iche, gụnyere HSV-1, HSV-2, VZV, HCMV, yana ụdị herpesvirus mmadụ ụdị 6 (HHV-6), ụdị 7 (HHV- 7) na ụdị 8 (HHV-8), na ịba ọcha n'anya B (HBV).Achọpụtara analogues guanosine ọhụrụ (ie A-5021 na D- na L-cyclohexenyl G) na-arụsi ọrụ ike megide nje ndị ahụ (HSV-1, HSV-2, VZV) nke na-edekọ maka otu thymidine kinase (TK), na-atụ aro. na ọrụ mgbochi ha (opekata mpe akụkụ) dabere na phosphorylation nke TK butere nje.A na-ahụkwa ọrụ antiviral akara na A-5021 megide HHV-6 yana D- na L-cyclohexenyl G megide HCMV na HBV.Ọrụ antiviral nke analogues acyclic/carbocyclic nucleoside nwere ike ịpụta nke ọma site na mycophenolic acid, onye na-egbochi inosine 5'-monophosphate (IMP) dehydrogenase.Ọhụrụ carbocyclic guanosine analogues (ie A-5021 na D- na L-cyclohexenyl G) na-ekwe nkwa dị ukwuu, ọ bụghị naanị dị ka antiviral ọrụ maka ọgwụgwọ nke herpesvirus-efe efe, kamakwa antitumor elekọta mmadụ maka ngwakọta genetherapy / chemotherapy nke cancer. ọ bụrụhaala na (akụkụ nke) mkpụrụ ndụ etuto ejirila nje virus (HSV-1, VZV) TK gbanwee.