Folic acid Cas: 59-30-3 99%
| Nọmba katalọgụ | XD90435 |
| Aha ngwaahịa | Folic acid |
| CAS | 59-30-3 |
| Usoro ihe omimi | C19H19N7O6 |
| Ibu molekụla | 441.40 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 29362900 |
Nkọwapụta ngwaahịa
| Ọdịdị | Odo ma ọ bụ oroma crystalline ntụ ntụ |
| Nyocha | 99% |
| Mmiri | 5.0-8.5% |
| Chromatographic ịdị ọcha | <2.0% |
| Solubility | Ihe na-adịghị ahụkebe na mmiri na ọtụtụ ihe mgbaze organic.Ọ na-agbaze na acid dilute na ngwọta alkaline |
| Ihe fọdụrụ na mgbanye | <0.3% |
N'ime ọmụmụ ihe a, thermosensitive na folate functionalized poly (ethylene oxide) -b-poly (propylene oxide) -b-poly (etylene oxide) -ploy (N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer bụ. synthesized.Ejiri 1H NMR, FT-IR na GPC kwadoro nhazi na ịdị arọ molekụla nke copolymer, n'otu n'otu.Okpomọkụ dị ala dị oke egwu (LCST) nke copolymer bụ 39.8 degrees C. Site n'iji doxorubicin (DOX) mee ihe dị ka ọgwụ nlereanya, folate receptor-ezubere iche DOX na-ebujuru micelles na-etolitekwa na copolymer.Miceles ndị ahụ oghere na DOX bujuru ha abụọ gosipụtara ihe fọrọ nke nta ka ọ bụrụ okirikiri na nkezi dayameta ha bụ 35 nm na 50 nm, n'otu n'otu.Àgwà ntọhapụ in vitro nke micelles DOX na-adabere na okpomọkụ na ọnụego ntọhapụ nke DOX na 42 degrees C (n'elu LCST) dị ngwa karịa nke ahụ na 37 degrees C (n'okpuru LCST).Ọzọkwa, nyocha nke cytotoxicity nke DOX efu na DOX na-ebufe micelles na ahịrị mkpụrụ ndụ kansa cervical cervical HeLa na ahịrị mkpụrụ ndụ kansa cancer akpa ume mmadụ A549 gosipụtara na folate na-abawanye nnabata cellular nke micelles n'ime sel ezubere iche nke na-egosipụta oke nnabata folate.
