Ngwaahịa

Flucytosine, nke a makwaara dị ka 5-fluorocytosine ma ọ bụ 5-FC, bụ ọgwụ antifungal synthetic nke a na-ejikarị eme ihe maka ọgwụgwọ nke ọrịa fungal.A na-ekewa ya dị ka antimetabolite, nke pụtara na ọ na-egbochi usoro metabolic nkịtị nke mkpụrụ ndụ fungal, na-eduga na mgbochi ma ọ bụ ọnwụ.A na-ejikarị Flucytosine na-ejikọta ya na ndị ọrụ antifungal ndị ọzọ maka ịrụ ọrụ kachasị mma. Otu n'ime isi ihe eji eme flucytosine bụ ọgwụgwọ nke ọrịa fungal na-emerụ ahụ, karịsịa ndị nke ụdị Candida na Cryptococcus kpatara.A na-ejikarị ya na ọgwụ nje ndị ọzọ, dị ka amphotericin B ma ọ bụ fluconazole, iji kwalite ọrụ antifungal.Flucytosine na-arụ ọrụ site na ịbanye na mkpụrụ ndụ fungal ma na-atụgharị n'ime 5-fluorouracil, cytotoxic antimetabolite.5-fluorouracil na-egbochi njikọ nke fungal RNA na DNA, si otú a na-egbochi uto fungal na mmụgharị.Usoro mmekọrịta a na-enyere aka ịlụso ụdị dị iche iche nke fungal pathogens ọgụ ma na-abawanye irè ọgwụgwọ.Ojiji ọzọ dị mkpa nke flucytosine bụ na ọgwụgwọ nke Cryptococcus neoformans meningitis, ọrịa nwere ike igbu ndụ nke na-emetụta akpụkpọ ahụ gbara gburugburu ụbụrụ na ọkpụkpụ azụ.A na-ewere Flucytosine dị ka otu n'ime usoro ọgwụgwọ mbụ yana amphotericin B maka ọgwụgwọ nke ọnọdụ a.Usoro ọgwụgwọ ngwakọta na-enyere aka imeri njedebe nke ọgwụ ọ bụla naanị ma nweta ọnụ ọgụgụ ọgwụgwọ dị elu.Flucytosine na-erute ọkwa zuru oke na mmiri cerebrospinal, na-enye ya ohere ka ọ rụọ ọrụ nke ọma maka ọrịa fungal na usoro nhụjuanya nke etiti. A pụkwara iji flucytosine mee ihe maka ọgwụgwọ nke ọrịa fungal ndị ọzọ, dị ka ọrịa nke ụfọdụ ụdị Candida na Aspergillus kpatara.Otú ọ dị, ojiji ya nwere ike ịdị oke n'ihi ihe ize ndụ nke ịmepụta nguzogide, dịka ero nwere ike nweta mmụgharị nke na-eme ka ọ ghara ịdaba na ọgwụ ahụ.Nleba anya na nyocha oge nke nzaghachi ọgwụgwọ dị mkpa mgbe ị na-eji flucytosine iji hụ na nsonaazụ ọgwụgwọ kwesịrị ekwesị. Ọ bụ ezie na flucytosine na-anabatakarị nke ọma, ọ nwere ike inwe mmetụta ọjọọ.Mmetụta ndị a na-emekarị na-agụnye nsogbu eriri afọ, dị ka ọgbụgbọ, vomiting, na afọ ọsịsa.O nwekwara ike ime ka mbelata ụmị ọkpụkpụ, nke nwere ike ịkpata mbelata mmepụta nke mkpụrụ ndụ ọbara.A na-eme nyocha ọbara mgbe niile iji nyochaa ọnụ ọgụgụ sel ọbara n'oge ọgwụgwọ. Na nchịkọta, flucytosine bụ ọgwụ na-egbu egbu nke a na-eji na ọgwụgwọ ngwakọta maka ọgwụgwọ ọrịa fungal, karịsịa ndị sitere na Candida na Cryptococcus ụdị.Ọ na-eme ihe site na itinye aka na njikọ nke nucleic acid fungal, na-egbochi uto na mmeghari ha.A na-ejikarị Flucytosine na ndị ọrụ antifungal ndị ọzọ na-ejikarị eme ihe ma dị oke mkpa na ọgwụgwọ nke Cryptococcus neoformans meningitis.Otú ọ dị, iji ya na-achọ nleba anya nke ọma n'ihi ihe ize ndụ nke iguzogide na mmetụta ọjọọ nwere ike ime.