Ngwaahịa

Mmetụta acidosis, ihe njirimara biochemical nke microenvironment tumor, na ọganihu cancer na metastasis dị mgbagwoju anya.A kọwo ma mmetụta pro- na mgbochi tumorigenic nke acidosis ma jiri microenvironment acid mee ihe maka nnyefe ọgwụ kpọmkwem, ndị na-ese foto, na mkpụrụ ndụ ihe nketa na-emepụta n'ime etuto ahụ.N'ime ọmụmụ ihe a, anyị na-enyocha mgbasawanye na ntinye uche nke mkpụrụ ndụ melanoma B16F10 bụ nke a na-emepụta site na mkpụrụ ndụ ihe nketa ka ọ pụta ìhè pH-sensing G protein-coupled receptor GPR4.Site n'iji nyocha mgbakwunye cell, anyị chọpụtara na GPR4 overexpression na-egbu oge ịgbasa cell ma gbanwee nhazi oghere nke mgbagwoju anya adhesion mgbagwoju anya, dị ka nhazi nke phosphorylated focal adhesion kinase (FAK) na paxillin, na pH acidic.Achọpụtakwara ụzọ mgbama G-protein nwere ike na mgbago ala bụ ndị na-akpata mmetụta ndị a.Site na iji Rho inhibitor CT04 (C3 transferase), Rho-associated kinase (ROCK) inhibitors Y27632 na thiazovivin, myosin light chain kinase (MLCK) inhibitor staurosporine ma ọ bụ ihe mgbochi G12/13, eweghachiri mgbasawanye cell ebe mgbochi na mgbochi. ịgbalite ụzọ Gq na Gs enwechaghị mmetụta ma ọ bụ enweghị mmetụta.N'ozuzu, nsonaazụ anyị na-egosi na site na ụzọ akara G12/13/Rho GPR4 na-emezigharị mgbanaka nrapagidesi ike ma na-ebelata mgbasa nke cell na nhịahụ.