Doxorubicin hydrochloride CAS: 25316-40-9 99% Oroma-acha uhie uhie Crystalline ntụ ntụ
| Nọmba katalọgụ | XD90367 |
| Aha ngwaahịa | Doxorubicin hydrochloride |
| CAS | 25316-40-9 |
| Usoro ihe omimi | C27H29NO11·HCl |
| Ibu molekụla | 579.98 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 29419000 |
Nkọwapụta ngwaahịa
| MmiriỌdịnaya | ≤ 4.0% |
| pH | 4.0-5.5 |
| Solubility | Soluble na: mmiri, methanol na isotonic NaCl (aq).Solubility na-adịghị mma na chloroform na ihe mgbaze organic ndị ọzọ. |
| Ihe ndị emetụtara | Doxorubicinone: ≤0.5% / Danunorubicin: ≤0.5% |
| Nyocha | 99% |
| Ihe mgbaze fọdụrụnụ | Acetone na mmanya: ≤2.5% / acetone: ≤0.5% / methanol: ≤500ppm |
| Ihe adịghị ọcha ọ bụla ọzọ | 0.5% |
| Mgbakọta adịghị ọcha | ≤2.0% |
| Crystallinity | Na-akwado USP |
| Ọdịdị | Oroma-acha ọbara ọbara kristal ntụ ntụ |
| njirimara | HPLC |
Ndị ọrịa nwere P-glycoprotein na HER2/neu (HER2) ndị na-anabata ọrịa ara ara na-enwekarị nsonaazụ na-adịghị mma.Otú ọ dị, ọ dịghị ahịrị mkpụrụ ndụ ọrịa ara ara na-ere ahịa nke dị na HER2/P-glycoprotein, nke na-egbochi nyocha na mpaghara a. Anyị na-akọ banyere mmepe na njirimara nke sub-akara na-eguzogide ọgwụ site na HER2-positive ara. ahịrị mkpụrụ ndụ kansa site na nfefe kwụsiri ike nke ATP-binding cassette (ABC) nke ezinụlọ B so 1 (ABCB1) gene nke na-edekọ P-glycoprotein.ABCB1 mkpụrụ ndụ mkpụrụ ndụ dị elu karịa mgbe ebufere ya, nke butere mmụba okpukpu 40 na P-glycoprotein. okwu.N'ụzọ na-akpali mmasị, nfefe nke ABCB1 mekwara ka mmụba dị nta na mkpụrụ ndụ HER2 na ọkwa okwu protein.Ntugharị nke ABCB1 mụbara ọkwa okwu P-glycoprotein nke ukwuu. Usoro eji eme ihe n'ime ebe a maka ịmepụta ahịrị sel a dabara adaba maka ngwa ngwa, nkwụsi ike nke nkwụsi ike nke P-glycoprotein-mediated ọgwụ tụnyere tr aditional ụzọ.Nnwale cytotoxicity in vitro na-egosi na ahịrị sel a nwere ihe mgbochi na-eguzogide ọtụtụ ọgwụ kemoterapi.
