Dirhodium tetraacetate CAS: 15956-28-2 99% kristal Green-oji
| Nọmba katalọgụ | XD90641 |
| Aha ngwaahịa | Dirhodium tetraacetate |
| CAS | 15956-28-2 |
| Usoro ihe omimi | C8H12O8Rh2 |
| Ibu molekụla | 441,987 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 28439000 |
Nkọwapụta ngwaahịa
| Ọdịdị | kristal Green-oji |
| Nyocha | 99% |
N7/O6 equatorial njikọ njikọ nke antitumor na-arụ ọrụ mgbagwoju anya Rh (2) (OAc) (4) (H (2) O) (2) (OAc (-) = CH (3) CO (2) (-)) ya na iberibe DNA d(GpG) ka ejirila NMR spectroscopy kpebisie ike n'enweghị mgbagha.Mkpebi X-ray crystallographic gara aga nke isi na isi (HH) na isi na ọdụ (HT) ntinye nke dirhodium tetraacetate na 9-ethylguanine (9-EtGH) kpughere nchikota N7 / O6 guanine nucleobases na-enwetụbeghị ụdị ya nke na-agbatị Rh. - Rh njikọ.Enweghị protonation N7 na pH dị ala yana mmụba pụtara ìhè na acidity nke N1-H (pK(a) ihe dịka 5.7 ma e jiri ya tụnyere 8.5 maka N7 naanị ejikọta platinum adducts), nke pH dabere na titrations nke purine H8 (1). H NMR resonances maka Rh (2) (OAc) (2) (9-EtG) (2) na Rh (2) (OAc) (2-) [d (GpG)], kwekọrọ na bidentate N7/O6 njikọ. nke guanine nucleobases.Ụkpụrụ pK (a) e mere atụmatụ maka N1-H (de) protonation, site na pH ndabere ọmụmụ nke C6 na C2 (13) C NMR resonances maka Rh (2) (OAc) (2) (9-EtG) 2) isomers, kwekọrịtara na t hose ewepụtara na titration resonance H8 (1) H NMR.Ntụle nke (13) C NMR resonances nke C6 na C2 maka dirhodium adducts Rh (2) (OAc) (2) (9-EtG) (2) na Rh (2) (OAc) (2) [d (GpG) )] na resonances kwekọrọ ekwekọ nke ligands unbound [na pH 7.0 maka 9-EtGH na pH 8.0 maka d (GpG)], na-egosi nnukwu mgbanwe ala ala nke Deltadelta dịka 11.0 na 6.0 ppm maka C6 na C2, n'otu n'otu;Mgbanwe nke ikpeazụ na-egosipụta mmetụta nke O6 na-ejikọta na ụlọ ọrụ dirhodium na nkwalite na-esote na acidity nke N1-H.Mkpokọta ọnụ nke H8/H8 ROE siri ike na 2D ROESY NMR spectrum nke Rh(2)(OAc)(2)[d(GpG)] na-egosi nhazi isi na isi nke ntọala guanine.Rh (2) (OAc) (2) [d (GpG)] adct na-egosiputa ndị na-eme aka nri abụọ, HH1 R na HH2 R, na HH1 R dị okpukpu atọ karịa HH2 R na-adịghị ahụkebe. Nkọwa zuru oke nke ha abụọ. adducts kpughere njakịrị nke mgbanaka shuga 5'-G na C3'-endo (N-ụdị), njigide nke C2'-endo (S-ụdị) conformation maka 3'-G sugar ring gs, na mgbochi nghazi n'ihe gbasara njikọ nke glycosyl.Atụmatụ nhazi nke enwetara maka Rh (2) (OAc) (2)) [d (GpG)] site na NMR spectroscopy dị nnọọ ka nke cis-[Pt (NH(3))) (2)) [d() GpG)] na nyocha ihe nlere anya nke mkpụrụ ndụ.
