Ngwaahịa

Iji nyochaa ọrụ nke nrụgide oxidative na / ma ọ bụ mmebi mitochondrial na ihe omume nke nnukwu mmerụ ahụ akụrụ (AKI) n'oge sepsis, anyị mepụtara ụdị sepsis na-akpata in vitro site na iji sel epithelial tubular proximal kpughere na endotoxin nje (lipopolysaccharide, LPS).Nchọpụta a ewepụtala njirimara ndị dị mkpa na mmekọrịta dị n'etiti nrụgide oxidative na ntụpọ ọrụ mitochondrial nke iku ume.Ọgwụgwọ LPS butere mmụba na ngosipụta nke nitric oxide synthase inducible (iNOS) na NADPH oxidase 4 (NOX-4), na-atụ aro cytosolic overexpression nke nitric oxide na superoxide anion, ụdị nitrogen na-emeghachi omume (RNS) na ụdị oxygen na-arụ ọrụ. (ROS).Ọnọdụ oxidant a yiri ka ọ kwụsịrị mitochondrial oxidative phosphorylation site na ibelata ọrụ cytochrome c oxidase.N'ihi nke a, nkwụsịtụ na njem elektrọn na proton na-agbapụ gafee akpụkpọ ahụ dị n'ime mitochondrial mere, na-eduga na mbelata nke ike nke mitochond rial membrane, mwepụta nke ihe na-ebute apoptotic na mbelata nke adenosine triphosphate.N'ụzọ na-akpali mmasị, mgbe RNS na ROS lekwasịrị anya, mitochondria ghọrọ onye na-emepụta ROS, si otú a na-enye aka n'ịbawanye nkwụsị nke mitochondrial.Ọrụ nke oxidants na mitochondrial dysfunction ka akwadoro site n'iji iNOS inhibitors ma ọ bụ antioxidants na-echekwa ọrụ cytochrome c oxidase ma gbochie mitochondrial membrane nwere ike ịgbasa.Nsonaazụ ndị a na-atụ aro na AKI nke sepsis na-ebute ọ bụghị naanị ka a ga-ewere ya dị ka ọdịda nke ọnọdụ ike kamakwa dị ka nzaghachi agbakwunyere, gụnyere ihe omume ederede, akara ROS, ọrụ mitochondrial na nhazi usoro metabolic dị ka apoptosis.