D-Glutamic acid CAS: 6893-26-1 99% ọcha ntụ ntụ
Nọmba katalọgụ | XD90313 |
Aha ngwaahịa | D-Glutamic acid |
CAS | 6893-26-1 |
Usoro ihe omimi | C5H9NO4 |
Ibu molekụla | 147.13 |
Nkọwa nchekwa | Ambient |
Koodu tarifu akwadoro | 29224200 |
Nkọwapụta ngwaahịa
Ọdịdị | White crystalline ntụ ntụ |
Nyocha | 99% |
Ntughari pụrụ iche | -31 ruo -32.2 |
Ọla dị arọ | <10ppm |
AS | <1pm |
pH | 3-3.5 |
SO4 | <0.020% |
Fe | <10ppm |
Ọnwụ na ihicha | <0.20% |
Ihe fọdụrụ na mgbanye | <0.10% |
NH4 | <0.02% |
Cl | <0.02% |
Ọnọdụ Ngwọta | > 98% |
γ-Glutamyltranspeptidases (γ-GTs) na-ekewa γ-glutamyl amide bond nke glutathione ma bufee otu γ-glutamyl n'ime mmiri (hydrolysis) ma ọ bụ amino acid na-anabata (transpeptidation).Enzymes ndị a dị n'ebe nile na-ekere òkè dị mkpa na biosynthesis na mmebi nke glutathione, na xenobiotic detoxification.Ebe a, anyị na-akọ 3Å mkpebi kristal Ọdịdị nke Bacillus licheniformis γ-GT (BlGT) na nke mgbagwoju ya na l-Glu.Ihe owuwu X-ray na-akwado na BlGT bụ nke N-terminal nucleophilic hydrolase superfamily wee kpughee na protein nwere oghere saịtị na-arụ ọrụ meghere dị ka nke akọọrọ maka enzyme homoloous sitere na Bacillus subtilis, mana dị iche na nke a hụrụ maka mmadụ γ-GT na maka γ-GT sitere na microorganisms ndị ọzọ.Data na-egosi na njiko nke l-Glu na-ebute nhazigharị ọdụ C-terminal nke BlGT nnukwu subunit ma kwe ka njirimara nke ụyọkọ nke foduru acid nke nwere ike itinye aka na njirimara nke ion ígwè.T ọrụ nke ndị a residues na conformational kwụsie ike nke BlGT e mụọ site characterizing na autoprocessing, enzymatic ọrụ, chemical na thermal denaturation nke anọ ọhụrụ Ala otu mutants.Nsonaazụ gosiri na nnọchi nke Asp568 na Ala na-emetụta ma nhazi autoprocessing na nkwụsi ike nke protein.