Ngwaahịa

Ọgwụgwọ mkpụrụ ndụ mammalian na ọgwụ chemotherapeutic nwere ike ibute nhụsianya nke ọdọ mmiri nucleotide.Ileba anya nhụsianya ndị a na mkpụrụ ndụ tumor mebere site na isi mmalite mmadụ bara uru maka nyocha nke mmetụta ọgwụgwọ ọgwụ na nghọta ka mma nke usoro nke ọgwụ ndị a.N'ime ọmụmụ ihe a, a na-eji klas atọ nke ọgwụ chemotherapeutic nwere usoro ọrụ dị iche iche na-emepụta ụdị mkpụrụ ndụ ọgwụ.A na-eme nyocha metabolomics lekwasịrị anya nke LC nke nucleotides na sel nke otu njikwa yana otu a na-agwọ ọgwụ.Ejikọtara ọtụtụ ụzọ nhazi data maka njirimara ndị nwere ike ime biomarkers metụtara omume nke ọgwụ, gụnyere nyocha otu ụzọ nke ọdịiche, isi ihe nyocha nke isi, na njiri njirimara ọrụ nnata.N'ụzọ na-akpali mmasị, mkpụrụ ndụ tumor nke ma ndị na-ahụ maka njikwa na ndị otu a na-agwọ ọgwụ nwere ike ịpụ iche na ibe ha, a na-amatakwa ọtụtụ mgbanwe dị ka potentia l biomarkers, dị ka ATP, GMP, na UDP maka ndị ọrụ antimetabolite, ATP, GMP, na CTP. maka ihe na-emebi DNA, yana GMP, ATP, UDP, na GDP maka ndị na-ahụ maka mkpịsị mkpịsị mitotic.Emere nkwado ọzọ nke ihe ndị nwere ike ime biomarkers site na iji usoro njirimara na-arụ ọrụ nke nnata.N'iburu n'uche na mpaghara ha kwekọrọ n'okpuru usoro ahụ, nke buru ibu karịa 0.9, enwere ike ikwubi na GMP na ATP bụ ihe kachasị mma maka biomarkers maka ọgwụ ndị na-emebi DNA, yana GMP, ATP, na UDP maka ọgwụ abụọ ndị ọzọ.Usoro nucleotide a nwere oke enweghị ike ịmatacha usoro nke ọgwụ itoolu ahụ kpamkpam, mana ọ na-enye ihe akaebe izizi maka ọrụ pharmacometabolomics na mmepe preclinical nke ọgwụ ọ dịkarịa ala.