Ngwaahịa

Cardioprotectant: Creatine phosphate bụ ihe dị mkpa na-enye ume na mkpụkọ akwara na metabolism.Ọ bụ ihe nchekwa ike kemịkalụ nke akwara dị nro na akwara dị warara, a na-ejikwa ya maka resynthesis ATP.Phosphocreatinedisodium bụ ụdị ọgwụgwọ ya.Sodium Creatine Phosphate, aha kemịkal N-[imino (phosphono) methyl]-N-methylglycine disodium nnu, bụ onye na-ahụ maka cardioprotective nke Italian Ouhui Pharmaceutical Factory malitere na 1992. Ụdị phosphocreatine na-arụ ọrụ dịgasị iche iche dị mkpa nke anụ ahụ, a na-ejikwa ya mee ihe n'ọtụtụ ebe. maka nchebe myocardial na ndị ọrịa nwere ischemia obi obi ma ọ bụ n'oge obi ịwa ahụ Chemicalbook, yana maka ọgwụgwọ ọrịa obi dị ka nkụchi obi, myocardial infarction na arrhythmia.Ọ nwere ike melite ọrụ obi yana mgbanwe ọnụọgụ obi na ndị ọrịa nwere cardiomyopathy ischemic.Ọ nwere ike ọ bụghị naanị inye ume maka mkpụrụ ndụ myocardial mgbe ha na-arịa ọrịa ischemia na hypoxia, kamakwa ọ na-echebe membranes cell myocardial site na mwakpo nke radicals free oxygen na ihe ndị ọzọ na-emerụ ahụ, nke nwere ike imetụta ọrụ obi.Nchedo myocardial mgbe arụchara ọrụ gasịrị na ndị ọrịa nwere ọrịa valvular na-adịghị mma na-aba uru maka mgbake nke ọrụ obi mgbe ọ gasịrị na ndị ọrịa nwere ọrịa valvular na-enweghị ike.Iji ya na-agwọ ọrịa myocardial nke ọma mgbe asphyxia nwa ọhụrụ nwere ike imeziwanye enzymes myocardial na electrocardiogram, ma nwee mmetụta ọgwụgwọ na nchekwa dị mma.

Njirimara ọrụ Ngwaahịa a bụ ihe nchekwa ike kemịkalụ nke obi na akwara skeletal, a na-ejikwa ya maka resynthesis nke ATP, na-enye ume maka usoro mkpirisi actomyosin, ma na-arụ ọrụ dị mkpa na metabolism ike nke mkpịsị akwara.Enweghi ike zuru oke bụ ihe dị mkpa na nhazi na mmepe nke mmerụ ahụ cell myocardial.

1. Ọ nwere mmetụta nchebe dị ịrịba ama na ọrụ systolic myocardial ischemic, nke nwere ike iweghachi nkwekọrịta zuru oke ma na-ebelata ọbara mgbali diastolic ngwa ngwa.

2. Na-edobe ọdịnaya nke adenosine triphosphate na creatine phosphate na sel, na Chemicalbook na-edobe nchekwa ike myocardial.

3. Belata mfu nke creatine kinase ma belata mmebi nke akpụkpọ ahụ cell.

4. O nwere ihe mgbochi peroxidation.

5. Meziwanye microcirculation myocardial.N'ihi ịdị adị nke njikọ phosphate dị elu na mkpụrụ ndụ creatine phosphate, njikọ phosphate dị elu nwere ike gbanwee ADP n'ime ATP ozugbo n'okpuru ọrụ creatine phosphate, ma nye ahụ ahụ ike ozugbo.Dị ka ngwaahịa etiti nke glycolysis, sodium fructose diphosphate kwesịrị ịrụ ọrụ na-apụtaghị ìhè site na metabolism anaerobic.

ụzọ sịntetik:

1 Iji dibenzyl phosphate dị ka akụrụngwa, meghachi omume na oxalyl chloride iji nweta dibenzyl oxyphosphoryl chloride;

2 N'okpuru ọrụ nke triethylamine, dibenzyloxyphosphoryl creatine ethyl ester nwetara site na mmeghachi omume ya na creatine ethyl ester hydrochloride na-cyclized na dibenzyloxyphosphoryl creatinine.

3. Mgbe palladium carbon catalyzed hydrogenolysis ka debenzylate, meghachi omume na sodium hydroxide iji nweta disodium creatinine phosphate,

4 bụ hydrolyzed ka ọ bụrụ 1 n'okpuru ọrụ nke sodium hydroxide.

Na-eji: Ọ dabara adaba maka ichebe metabolism myocardial na-adịghị mma na steeti ischemia myocardial.

Mmeghachi omume ọjọọ, contraindications na mmetụta ọgwụ: a machibidoro ndị nwere ihe nfụkasị ahụ na akụkụ nke ngwaahịa a;Amachibidoro ndị nwere ụkọ akụrụ na-adịghị ala ala iji nnukwu doses (5-10g/d).Ịgba ogwu ogbugba ngwa ngwa karịa 1g nwere ike ime ka mbelata ọbara mgbali elu.Nlekọta dị elu na-ebute oke phosphate oriri, nke nwere ike imetụta calcium metabolism na secretion nke homonụ na-achịkwa homeostasis, na-emetụta ọrụ akụrụ na purine metabolism.