Ngwaahịa

Clopidogrel camphorsulfonate bụ ọgwụ ọgwụ nwere usoro kemịkalụ C16H16ClNO2S·C10H16O4S.A na-akpọkarị Clopidogrel S-oxide camphorsulfonate ma ọ bụ Clopidogrel CAMS.Ngwakọta a bụ ihe sitere na chiral nke clopidogrel, nke bụ ọgwụ antiplatelet a na-ejikarị eme ihe. Ojiji mbụ nke Clopidogrel camphorsulfonate bụ ihe na-arụsi ọrụ ike n'imepụta ọgwụ antiplatelet.Ọ na-arụ ọrụ site na igbochi nchịkọta platelet, igbochi mkpụkọ ọbara, na ibelata ihe ize ndụ nke ihe omume obi.Ngwakọta ahụ na-elekwasị anya kpọmkwem onye na-anabata P2Y12 na platelet, si otú a na-egbochi usoro ịgbalite na igbochi nchịkọta platelet.Usoro ihe omume a na-eme ka Clopidogrel camphorsulfonate dị irè n'igbochi thrombosis nke akwara akwara na ibelata ihe omume nke ọrịa obi, gụnyere nkụchi obi na ọrịa strok.Ozugbo etinyere ya, a na-eme mgbanwe nke metabolic na imeju, nke na-ebute nguzobe nke metabolite na-arụ ọrụ.Metabolite a na-arụ ọrụ na-ejikọta ya na onye na-anabata P2Y12, na-arụ ọrụ antiplatelet ya ruo ogologo oge.Ngwakọta ahụ nwere ogologo oge na-arụ ọrụ, na-achọ dose otu ugboro kwa ụbọchị n'ọtụtụ ọnọdụ. N'ime usoro ọgwụgwọ, a na-enyekarị Clopidogrel camphorsulfonate maka ndị ọrịa nwere nnukwu ọrịa obi na-arịa ọrịa obi, dị ka angina na-adịghị eguzobe na myocardial infarction, ma ọ bụ ndị na-enweta ọrịa obi na-akpata percutaneous. ntinye aka (PCI) na ntinye stent.A na-ejikwa ya n'ọtụtụ ebe iji gbochie ihe omume thrombotic na ndị ọrịa nwere akụkọ ihe mere eme nke ọrịa strok ma ọ bụ ọrịa akwara dị n'akụkụ.A na-ejikọta ojiji nke Clopidogrel camphorsulfonate na ọgwụ aspirin dị ala iji kwalite ọgwụgwọ antiplatelet. ọnụ ọgụgụ ndị ọrịa.Usoro onunu ogwu na oge ọgwụgwọ nwere ike ịdịgasị iche dabere na ọnọdụ ahụike nke onye ahụ, yana nleba anya na ọrụ platelet na nyocha ọbara nwere ike ịdị mkpa iji hụ na nsonaazụ ọgwụgwọ kacha mma. karịsịa ndị metụtara thrombosis arterial.Njirimara antiplatelet ya na mmachi nhọrọ nke onye na-anabata P2Y12 na-eme ka ọ bụrụ ọgwụ dị irè maka ibelata ihe egwu nke ihe omume obi na obi.Agbanyeghị, dịka ọ dị n'ụdị ọgwụ ọ bụla, ekwesịrị ịkpachara anya n'iji ya eme ihe, yana ndị ọrịa kwesịrị ịgbaso ndụmọdụ na ntuziaka onye nlekọta ahụike ha.