Ngwaahịa

Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride bụ ngwakọta kemịkalụ nke na-achọta ngwa n'ọhịa nke kemịkalụ ọgwụ na mmepe ọgwụ.Nhazi molekụla ya nwere mgbanaka pyrrolidine nwere otu tert-butyl na ọnọdụ cis, otu ethyl na otu carboxylate abụọ.A na-ahụkarị ogige a n'ụdị nnu hydrochloride. Otu n'ime isi ojiji nke cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride bụ na njikọ na mmepe nke ọgwụ na-elekwasị anya na etiti. usoro ụjọ (CNS).Ọnụnọ nke mgbanaka pyrrolidine, yana otu tert-butyl na ethyl, na-enye onyinye a nwere ihe ndị nwere ike ime ihe na-adịghị mma.Ndị na-eme nchọpụta nwere ike iji onyinye a dị ka ihe mmalite iji mepụta analogs ma ọ bụ ihe mmepụta nke nwere ike ịhọrọ nke ọma na ndị na-anabata ya ma ọ bụ enzymes dị na CNS.Site n'ịgbanwe nhazi na ihe ndị na-anọchi anya ya, ha nwere ike ịkwalite ihe ndị na-emepụta ọgwụ na-emepụta ọgwụ, na-eme ka njikọ nke onye na-anabata ya dịkwuo mma, ma melite ikike ọgwụgwọ ya. Ọzọkwa, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride nwere ike ịbụ. A na-arụ ọrụ dị ka ngwa ngwa na ọmụmụ ihe gbasara ndụ iji nyochaa ọrụ nke ndị na-anabata ya ma ọ bụ enzymes na usoro akwara ozi.Site n'iji onyinye a dị ka ligand ma ọ bụ nyocha, ndị nchọpụta nwere ike nyochaa njikọ njikọ, nhọrọ, na usoro nke ndị na-anabata ma ọ bụ enzymes.Ozi a dị oke mkpa maka ịghọta ihe ndabere mkpụrụ ndụ nke usoro neuropharmacological na mmepe nke usoro ọgwụgwọ ọhụrụ na-elekwasị anya na ọrịa neurodegenerative, ọnọdụ uche, ma ọ bụ ọrịa akwara ozi. Ngwa ahụ nwekwara ngwa nwere ike na nchọpụta ọgwụ na nyocha nyocha dị elu.Enwere ike itinye ya n'ọba akwụkwọ nke ogige, nke a na-enyocha megide ebumnuche dị iche iche, dị ka ndị na-anabata ma ọ bụ enzymes, iji chọpụta ogige ndu ma ọ bụ ndị na-achọ ọgwụ.Nyocha a na-enye ohere maka njirimara nke ogige ndị na-egosipụta ihe ndị a na-achọsi ike na ọgwụ ọgwụ ma ọ bụ mmetụta ọgwụgwọ nwere ike. Ọzọkwa, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride nwere ike ịchọta uru na mmepe nke prodrugs.Prodrugs bụ ndị na-adịghị arụ ọrụ ma ọ bụ ndị na-adịghị arụ ọrụ ogige nke emebere ka metabolized n'ime ụdị ọrụ ha otu ugboro n'ime ahụ.Site n'ịgbanwe nhazi nke ogige a, ndị nchọpụta nwere ike ịmepụta ụdị prodrug ndị kwụsiri ike, mee ka bioavailability dịkwuo mma, ma ọ bụ nwee ike ịgafe akpụkpọ anụ dị ndụ n'ụzọ dị mfe.Nke a nwere ike ịkwalite uru ọgwụgwọ ọgwụgwọ ahụ ma melite akụrụngwa ọgwụ ya. Na nchịkọta, cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride bụ ihe nwere ike itinye ngwa na mmepe nke ọgwụ CNS ezubere iche. , dị ka ngwa ngwa maka ọmụmụ ihe ọmụmụ ihe ndụ, na nchọpụta ọgwụ, na mmepe nke prodrugs.Ọdịdị molekụla ya pụrụ iche na-enye ohere maka mgbanwe na njikarịcha iji kwalite akụrụngwa ọgwụ ya na ihe omume ndụ.Ntughari na ikike nke onyinye a na-eme ka ọ bụrụ ihe bara uru na ngalaba nke ọgwụ ọgwụ na mmepe ọgwụ.