Ngwaahịa

thrombin-activatable fibrinolysis inhibitor (TAFIa) bụ carboxypeptidase nwere zinc ma na-egbochi fibrinolysis nke ukwuu.Ya mere, a na-atụ anya ka ndị na-egbochi TAFIa na-eme ihe dị ka ndị ọrụ profibrinolytic.N'oge na-adịbeghị anya, anyị kọrọ atụmatụ na njikọ nke ndị na-egbochi TAFIa nwere selenium na ọrụ mgbochi ha.N'ebe a, anyị na-akọpụta ihe owuwu kristal nke selenium-, sọlfọ-, na phosphinic acid nwere inhibitors nwere ike jikọta na porcine pancreatic carboxypeptidase B (ppCPB).ppCPB bụ TAFIa homologue ma bụrụ onye nnọchi anya TAFIa maka nyocha crystallographic.Akụkụ kristal nke ppCPB gbajuru ya na selenium compound 1a, sulfur analogue 2, na phosphinic acid derivative EF6265 ka e kpebiri na mkpebi 1.70, 2.15, na 1.90 Å, n'otu n'otu.Onye na-egbochi onye ọ bụla na-ejikọta na saịtị ppCPB na-arụ ọrụ n'otu aka ahụ na nke a hụrụ maka ndị na-egbochi ndị na-eme ihe na mbụ.Ya mere, na ogige, selenium, sọlfọ, na phosphinic acid oxygen na-ahazi zinc na ppCPB.Nke a bụ nleba anya na akụkọ gbasara nhazi nke selenium na zinc na CPB.