Albendazole Cas: 54965-21-8
| Nọmba katalọgụ | XD91873 |
| Aha ngwaahịa | Albendazole |
| CAS | 54965-21-8 |
| Ụdị molekụlala | C12H15N3O2S |
| Ibu molekụla | 265.33 |
| Nkọwa nchekwa | 2-8 Celsius C |
| Koodu tarifu akwadoro | 29332990 |
Nkọwapụta ngwaahịa
| Ọdịdị | White crystalline ntụ ntụ |
| Asay | 99% nkeji |
| Ebe mgbaze | 208-210 Celsius C |
| njupụta | 1.2561 (atụmatụ siri ike) |
| index refractive | 1.6740 (atụmatụ) |
| solubility | Nke a na-adịghị ahụkebe n'ime mmiri, na-agbaze kpamkpam na anhydrous formic acid, soluble dị ntakịrị na methylene chloride, ihe fọrọ nke nta ka ọ bụrụ ihe a na-adịghị ahụkebe na ethanol (pasent 96). |
| pka | 10.72± 0.10 (buru amụma) |
| Mmiri Solubility | 0.75mg/L (209ºC) |
Albendazole bụ ọgwụ a na-eji agwọ ọrịa nje ndị nje na-akpata.Enwere ike inye ya ọgwụgwọ ọrịa ụbụrụ na-adịghị ahụkebe (neurocysticercosis) ma ọ bụ enwere ike inye ya iji gwọọ ọrịa nje na-akpata afọ ọsịsa dị mkpa (microsporidiosis).
Mwepụta nke benzimidazole, albendazole bụ ọgwụ nwere ụdị antihelmintic sara mbara.Ọ na-egosipụta mmetụta antihelmintic megide cestodes na nematodes dị nro site na igbochi usoro nnabata glucose site na nje nje, nke egosipụtara na mbelata nke glycogen na mbelata ọkwa nke adenosintriphophate.N'ihi ya, parasaiti ahụ kwụsịrị ịkwagharị wee nwụọ.A na-eji ya maka ọrịa nke Acaris lumbricoides, Ancylostoma duodenale, Necator americanus, Enterobius vermicularis, na Trichuris trichiura.Njikọ ọgwụ a bụ SKF 62979 na ndị ọzọ.
Methyl 5- (propylthio) -2-benzimidazolecarbamate (Eskazole, Zentel) bụ anthelmintic sara mbara nke anaghị ere ahịa ugbu a na North America.Ọ dị n'aka onye nrụpụta na ndabere iji ọmịiko.A na-eji Albendazole n'ụwa niile maka ọgwụgwọ ọrịa intestinalnematode.Ọ dị irè dị ka ọgwụgwọ otu dose maka ascariasis, New na Old World hookworm ọrịa, na trichuriasis.Usoro ọgwụgwọ ọtụtụ dose na albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, na ọrịa hydatid.Ịdị irè nke albendazole megidetapeworms (cestodes) na-agbanwekarị ma na-enwechaghị mmetụta.
Albendazole na-eme dị ka ntụ ntụ kristal na-acha ọcha nke na-adịghị edozi na mmiri.A na-eme ka mmịnye ọnụ nke albendazole dị mma site na nri nwere abụba.Ọgwụ a na-enweta ngwa ngwa na nnukwu nnabata nke mbụ na sulfoxide, nke bụ ụdị na-arụ ọrụ na plasma.Ọkara ndụ nke sulfoxide mkpochapụ sitere na awa 10 ruo 15.A na-eme ka biliary excretion na enterohepatic megharịa albendazolesulfoxide.A na-anabata Albendazole nke ọma na ọgwụgwọ otu dose maka nematodes eriri afọ.Ọgwụ dị elu, ọgwụgwọ ogologo oge achọrọ maka ọgwụgwọ ọrịa ọrịa clonorchiasis orechinococcal nwere ike ibute nsonaazụ dị njọ dị ka ụmị ọkpụkpụ, mmụba nke enzymes imeju, na alopecia.
Albendazole nwere ọtụtụ ọrụ dị iche iche megide nematodes eriri afọ na cestodes, yana flukes imeju Opisthorchis sinensis, Opisthorchis viverrini, na Clonorchis sinensis.Ejikwa ya nke ọma megide Giardia lamblia.Albendazole bụ ọgwụgwọ dị irè nke ọrịa hydatid cystitis (echinococcosis), karịsịa mgbe a na-esonyere ya na praziquantel.Ọ dịkwa irè n'ịgwọ ọrịa cerebral na spinal neurocysticercosis, karịsịa mgbe a na-enye ya na dexamethasone. A na-atụ aro Albendazole maka ọgwụgwọ gnathostomiasis.
