Ngwaahịa

Ihe akaebe na-adịbeghị anya na-akwado ọrụ na-apụta nke β-nicotinamide adenine dinucleotide (β-NAD (+)) dị ka neurotransmitter novel na neuromodulator na sistemu ụjọ nke akụkụ -β-NAD (+) na-ewepụta na nkwadebe akwara dị nro na sel chromaffin adrenal. n'ụzọ e ji mara neurotransmitter.Ugbu a amabeghị ma nke a ọ̀ bụ eziokwu maka CNS.N'iji nyocha nyocha nke obere ụlọ superfusion na usoro chromatography mmiri dị elu nke nwere mmetụta dị elu, anyị na-egosi na elu-K (+) mkpali nke ụbụrụ ụbụrụ ụbụrụ synaptosomes na-akpalite oke nke β-NAD (+), adenosine 5'-triphosphate, na ha. metabolites adenosine 5'-diphosphate (ADP), adenosine 5'-monophosphate, adenosine, ADP-ribose (ADPR) na cyclic ADPR.A na-ebelata oke-K (+) -wepu nke β-NAD (+) site na nkwụsị nke SNAP-25 na botulinum neurotoxin A, site na mgbochi nke N-ụdị voltaji dabere Ca (2+) ọwa na ω-conotoxin GVIA. , na site na mgbochi nke proton gradient nke synapti vesicles na bafilo mycin A1, na-atụ aro na β-NAD (+) nwere ike ịpụta site na vesicle exocytosis.Nyocha Western na-egosi na CD38, protein multifunctional nke na-emepụta β-NAD (+), dị na membranes synaptosomal na cytosol.Synaptosomes na-emebi emebi na-eweda β-NAD(+) .1,N (6) -etheno-NAD, analog fluorescent nke β-NAD (+), na-ewere synaptosomes na nke a na-ebelata site na ezigbo β-NAD (+), ma ọ bụghị site na connexin 43 inhibitor Gap 27. Na cortical neurons ngwa mpaghara nke β-NAD (+) na-eme ka ngwa ngwa Ca (2+) na-agafe agafe, ikekwe n'ihi ntinye nke Ca(2+) extracellular.Ya mere, ụbụrụ ụbụrụ synaptosomes nwere ike ịgbahapụ, mebie na iwelie β-NAD (+), na β-NAD (+) nwere ike kpalie neurons postsynaptic, ihe niile achọrọ maka ihe a ga-ewere dị ka onye na-eme nchọpụta neurotransmitter na ụbụrụ.