Ngwaahịa

6-Acetyl-8-cyclopentyl-5-methyl-2-[5- (1-piperazinyl) -2-pyridinyl] amino] pyrido [2,3-d] pyrimidin-7 (8H) - otu hydrochloride bụ ngwakọta. nwere ike ngwa na nyocha ọgwụ na mmepe ọgwụ.Usoro ihe omimi ya pụrụ iche na-enye ohere maka nyocha n'ime ọgwụgwọ ọgwụgwọ ya. Ngwa a bụ nke ezinụlọ pyrido [2,3-d] pyrimidinone, bụ nke a na-amụkarị maka ọrụ ọgwụ ya.Ọnụnọ nke otu acetyl na-egosi mmekọrịta nwere ike ime na enzymes na-etinye aka na usoro cellular.O nwere ike inwe mmetụta mgbochi na enzymes dị ka kinases ma ọ bụ proteases, na-eme ka ọ bụrụ onye na-ekwe nkwa maka mmepe nke ndị na-eme ihe na-emepụta enzyme kpọmkwem. Ndị cyclopentyl na methyl dị na nhazi ahụ na-enye aka na ọdịdị lipophilic nke ogige ahụ.Ihe onwunwe a na-enye ya ohere ịgafe ihe mgbochi ndu n'ụzọ dị mfe, na-abawanye ikike ya dị ka onye na-achọ ọgwụ.O nwere ike ime ka ọ dịkwuo mma na bioavailability, na-eme ka ọ dị mma maka nchịkwa ọnụ na nkesa usoro. Otu 1-piperazinyl na 2-pyridinyl dị na ogige ahụ na-enye ohere maka iji ya mee ihe n'ichepụta ọgwụ.A na-amata usoro piperazine na kemistri ọgwụ maka ọrụ ndụ ha.Otu piperazine nwere ike inye aka na njikọ nke ndị na-anabata ya ma gbanwee akụrụngwa ọgwụ.Ọzọkwa, otu pyridine na-etinyekarị aka na mmekọrịta ligand-receptor, dị ka usoro mgbanaka pyridine nwere ike ịmepụta njikọ hydrogen na saịtị ndị na-anabata ya.Ngwongwo ndị a na-eme ka onyinye a bụrụ ihe nwere ike ime ka ndị na-anabata ya dị iche iche, gụnyere G protein-coupled receptors. N'ịtụle pyrido [2,3-d] pyrimidinone scaffold na ọnụnọ nke otu piperazine, enwere ike nyochaa ogige ahụ dị ka onye na-egbochi ọrịa cancer. .Ọ nwere ike igosipụta mmetụta cytotoxic megide mkpụrụ ndụ kansa site na mgbochi nke ụzọ mgbaàmà akọwapụtara nke metụtara mmụba cell.Ọmụmụ ihe ndị ọzọ metụtara in vitro na ụdị vivo nwere ike nyochaa ikike ya dị ka onye na-ahụ maka mgbochi tumor. Ọzọkwa, pyrido [2,3-d] pyrimidinone isi nwere ike gbanwee iji kwado ọrịa ma ọ bụ ọnọdụ ụfọdụ.Site na iwebata otu ma ọ bụ ihe ndị na-arụ ọrụ kwesịrị ekwesị, nhọrọ ya na ike ya nwere ike ime ka ọ dịkwuo mma, na-enye ohere maka ịmepụta ọgwụgwọ ọgwụgwọ dị oke mkpa. Na nchịkọta, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5--1- piperazinyl) -2-pyridinyl] amino] pyrido [2,3-d] pyrimidin-7 (8H) -otu hydrochloride na-ejide ike n'ọtụtụ ebe nyocha ọgwụ.Njirimara nhazi ya na-enye ohere maka nyocha banyere mgbochi enzyme, njikọ ndị na-anabata ya, na ọrụ mgbochi ọrịa cancer.Nchọgharị ọzọ na njikarịcha ihe nhazi ya nwere ike inye ndị na-achọ ọgwụ ọhụrụ nwere arụmọrụ dị mma na nkọwapụta maka ebumnuche ọgwụgwọ dị iche iche.