5-Nitro-1,10-phenanthroline CAS:4199-88-6 Ìhè edo edo ka kristal aja aja
| Nọmba katalọgụ | XD90385 |
| Aha ngwaahịa | 5-Nitro-1,10-phenanthroline |
| CAS | 4199-88-6 |
| Usoro ihe omimi | C12H7N3O2 |
| Ibu molekụla | 225.21 |
Nkọwapụta ngwaahịa
| Ebe mgbaze | 200-203 Celsius C |
| Nyocha | 99% |
| Ọdịdị | Agba odo ruo kristal aja aja |
Achịkọtala metallointercalators nke platinum iri na ise (II) nke na-eji 1,10-phenanthroline (phen) ligands dochie anya, gụnyere 5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) na dipyrido [3,2-d] : 2',3'-f] quinoxaline (dpq), na achiral ethylenediamine (en) na chiral ancillary ligands 1S,2S-diaminocyclohexane (S, S-dach) na 1R,2R-diaminocyclohexane (R, R-dach) .Achọpụtara cytotoxicity ha na ahịrị mkpụrụ ndụ leukemia murine L1210 site na iji nyocha mgbochi uto.Ihe mgbagwoju metal cytotoxic kachasị bụ ndị nwere S, S-dach ancillary ligands na 5-CH3-phen intercalating ligands.Otu metallointercalator [Pt (5-CH3-phen) (S, S-dach)] Cl2 (5MESS), na-egosiputa mmụba okpukpu 5-10 na cytotoxicity ma e jiri ya tụnyere onye nnọchi anya cisplatin.Site na nnwale njikọ DNA, ọ dị ka enweghị nnukwu ọdịiche dị n'etiti ogige ọla ọ bụla, na-egosi na ọbụghị njikọ DNA na-ejikọta ma ọ bụ ụdị njide / DNA etinyere bụ naanị ihe na-ekpebi cytotoxicity nke ezinụlọ platinum (II) dabere. metallointercalators.
