Ngwaahịa

1. Ebumnuche nke ọmụmụ a bụ ịmepụta ụdị pharmacokinetic-pharmacodynamic (PK-PD) dị mfe nke nwere ike ịkọwapụta oge zuru oke nke mgbanwe na ọnụ ọgụgụ platelet iji buru amụma mmalite na ogo thrombocytopenia, nke na-egbochi oke iji ọgwụ. onye na-ahụ maka ọrịa cancer 5-fluorouracil (5-FU), na oke.2. A na-atụle ọnụ ọgụgụ platelet na oke na-esote nchịkwa intravenous nke usoro dị iche iche nke 5-FU maka ụbọchị 4 iji nweta data maka nyocha nke ụdị PK-PD.Ụdị PK-PD anyị nwere ụdị PK nwere akụkụ abụọ, nwere akụkụ atọ maka ụdị PD yana 10 nhazi ụdị PK-PD.3. Mgbe ọgwụgwọ 5-FU gasịrị, ọnụ ọgụgụ platelet na-ebelata n'oge na-adịghị anya ruo ọkwa nadir, gosipụtara nlọghachi n'elu ọkwa ntọala tupu ọ gbakee na ọkwa ọkwa.Ọnụọgụ platelet na nkwụghachi azụ dịgasị iche na ọkwa AUC0-∞.Ụdị PK-PD nke ikpeazụ ji mara data ọnụ ọgụgụ platelet nke ọma yana nkeji PD ikpeazụ ka e jisiri ike mee atụmatụ.4. Nke a PK-PD nlereanya na ịme anwansị nwere ike ịnọchite anya ngwá ọrụ bara uru maka ịkọwapụta na ịkọ oge zuru oke nke mgbanwe na ọnụ ọgụgụ sel ọbara, ma nwee ike inye aka na mmepe nke usoro ọgwụgwọ na 5-FU na nyocha nke ndị na-ahụ maka ọrịa cancer dị iche iche. nke siri ike inyocha n'ime mmadụ.