Ngwaahịa

4-Chloro-2-fluoro-3-methoxyphenylboronic acid bụ chemical compound nke nwere ngwa dị iche iche na organic synthesis, ọgwụ kemịkalụ, na ihe sayensị.One nke isi ojiji nke 4-Chloro-2-fluoro-3-methoxyphenylboronic acid bụ. na mgbanwe metal-catalyzed cross-njikọ mmeghachi omume.Ọ na-eje ozi dị ka ihe mgbochi ụlọ boronic acid, na-enye ohere maka ịmepụta carbon-carbon ma ọ bụ carbon-heteroatom bond.Dịka ọmụmaatụ, enwere ike iji onyinye a na mmeghachi omume njikọta nke Suzuki-Miyaura, ebe ọ na-emeghachi omume na aryl ma ọ bụ vinyl halides n'okpuru palladium catalysis iji mepụta ogige biaryl.Ndị a cross-njikọ mmeghachi omume na-ọtụtụ ebe n'ọrụ na njikọ nke mgbagwoju organic ụmụ irighiri ihe, gụnyere pharmaceuticals na agrochemicals, nakwa dị ka ewu organic material.The pụrụ iche Nchikota chlorine, fluorine, na methoxy iche iche na Ọdịdị nke 4-Chloro-2 -fluoro-3-methoxyphenylboronic acid na-enyere aka njikọ nke ụdị dị iche iche nwere ahaziri ahazi.Atọm chlorine nwere ike ije ozi dị ka otu na-eduzi n'usoro ngbanwe metal-catalyzed, na-eduzi mmeghachi omume na-ahọrọ na saịtị ndị akọwapụtara n'ime molecule.Mgbanwe nke fluorine na-enye nkwalite lipophilicity, nke nwere ike imetụta akụrụngwa ọgwụ na-emepụta ọgwụ ma melite bioavailability ya.Otu methoxy, n'aka nke ọzọ, nwere ike ime dị ka otu nchebe ma ọ bụ sonye na mgbanwe kemịkalụ dị iche iche.Na ọgwụ ọgwụ, 4-Chloro-2-fluoro-3-methoxyphenylboronic acid na ihe ndị na-emepụta ya nwere mmasị dị ka ndị nwere ike ịme ọgwụ.Otu ndị na-arụ ọrụ dị ka chlorine na fluorine nwere ike imezi mmekọrịta nke ogige ahụ na ebumnuche ndu ma melite akụrụngwa ọgwụ ya.Na mgbakwunye, otu methoxy nwere ike ịkwalite nkwụsi ike nke ihe mejupụtara ya ma tinye aka na lipophilicity na solubility ya.Ihe ndị a na-eme ka 4-Chloro-2-fluoro-3-methoxyphenylboronic acid bụrụ mmalite bara uru maka ịmepụta ihe ọhụrụ ọgwụgwọ ọgwụgwọ na ubi dị ka oncology, ọrịa na-efe efe, na mbufụt. Ọzọkwa, boronic acid moiety na 4-Chloro-2-fluoro. -3-methoxyphenylboronic acid nwere ike ime ka guzobe nke boronate esters kwụsiri ike, nke ejirila mee ihe n'ichepụta ihe nwere ihe pụrụ iche.Ihe ndị a nwere ike igosipụta ngwa anya, eletrọnịkị, ma ọ bụ catalytic, dabere na nhazi na nhazi ha.Ntinye nke 4-Chloro-2-fluoro-3-methoxyphenylboronic acid ma ọ bụ ihe ndị na-emepụta ya n'ime ihe ndị a nwere ike inye ọrụ dị iche iche ma kwalite ọrụ ha. n'ihi kemịkalụ ya dị iche iche na ikike imepụta ụmụ irighiri ihe na ihe ndị na-arụ ọrụ.Ọrụ ya na ngbanwe metal-catalyzed njikọta mmeghachi omume, jikọtara ya na ihe pụrụ iche nke ndị otu ya na-arụ ọrụ, na-eme ka ọ bụrụ ngwá ọrụ bara uru na njikọ organic na kemistri ọgwụ.Na mgbakwunye, moiety boronic acid na-enyere aka guzobe boronate esters, nke na-enye aka n'ịmepụta ihe dị elu nwere njirimara ahaziri.