4-Aminophthalhydrazide AMPPD Cas: 3682-14-2 Ìhè na-acha odo odo ka amber ruo ọchịchịrị akwụkwọ ndụ akwụkwọ ndụ ntụ ntụ ka akpụ akpụ
| Nọmba katalọgụ | XD90156 |
| Aha ngwaahịa | 4-Aminophthalhydrazide |
| CAS | 3682-14-2 |
| Usoro ihe omimi | C8H7N3O2 |
| Ibu molekụla | 177.16 |
| Nkọwa nchekwa | Ụlọ ahịa na RT |
Nkọwapụta ngwaahịa
| Ọdịdị | Ọkụ na-acha odo odo ruo amber ruo ntụ ntụ gbara ọchịchịrị ka ọ kpọọ nkụ |
| Asay | ≥98.0% |
| Njupụta | 1.433 |
| Ebe mgbaze | 300ºC |
| Ebe esi nri | 633°C na 760 mmHg |
| ebe mgbari | 336.7C |
| Solubility | Soluble na ammonium hydroxide, sodium carbonate ma ọ bụ ntọala ndị ọzọ. |
1.We nyochaa ma tụnyere mmetụta nke ise H1-anthistamines na kpaliri oxidative gbawara na extra- na intracellular larịị nke dịpụrụ adịpụ na kpaliri mmadụ polymorphonuclear leukocytes.Oxidative gbawara nke dịpụrụ adịpụ neutrophils mmadụ a mụrụ site na luminol na isoluminol enwekwukwa chemiluminescence. Ndị na-esonụ A na-enyocha ọkwa nke ike maka H1-anthistamines iji belata chemiluminescence extracellularly: dithiaden> loratadine> chlorpheniramine> brompheniramine> pheniramine na na saịtị intracellular: loratadine> dithiaden.H1-anthistamines dị iche iche dabere na usoro kemịkalụ ha abụọ na-eme ihe na-eme ka ihe na-egbochi oxidative. - na saịtị intracellular nke neutrophils mkpali mmadụ dịpụrụ adịpụ.
Usoro 2.Chemiluminescence kwalitere ma ọ bụ isoluminol ma ọ bụ luminol jikọtara ya na peroxidase bụ ụzọ dị nro maka ịchọpụta ụdị oxygen reactive (ROS) nke phagocyte NADPH oxidase mepụtara.Ihe abụọ na-eme ka ụda olu na-eme ka ọ bụrụ otu n'ụdị, dị iche iche naanị n'ọkwa otu amino na mgbanaka aromatic nke ụmụ irighiri ihe.Ọdịiche a na-eme ka isoluminol bụrụ molekul lipophilic dị ntakịrị nke na-adịchaghị agafe n'ahụ akpụkpọ anụ.N'ihi ya, a na-amachibido iji isoluminol na ọmụmụ ihe gbasara nzuzo nke metabolites oxygen.N'ime ọmụmụ ihe a, anyị na-egosi na peptides sịntetik sitere na ngalaba N-terminal nke calcium-regulated protein annexin AI na-egbochi nchọpụta nke radicals na isoluminol-amplified, ma ọ bụghị na luminol-amplified, usoro.Annexin AI-enwetara peptides na-ebelata mmepụta ọkụ na isoluminol nwere obi ụtọ site na superoxide na horseradish peroxidase (HRP) na formyl-methionyl-leucyl-phenylalanine- na phorbol my ristate acetate-stimulated cell, yana site na hydrogen peroxide na HRP.A maghị usoro ziri ezi maka mgbochi ahụ.Nsonaazụ ewepụtara nke ọma na-atụ aro na a ga-akwado nzaghachi ekwentị mbelata nke nwere kemiluminol-amplified chemiluminescence site na usoro ọzọ iji chọpụta mwepụta nke anions superoxide na hydrogen peroxide.
