A na-enye oke otu dose nke osisi sitere na phenolic antioxidant Quercetin (QC) n'efu, liposome encapsulated na galactosylated liposome encapsulated 2 h tupu hepatotoxic dose nke carbontetrachloride (CCl4, 40% v / v na mmanụ oliv, 1 ml / kg b) .wt).N'ime ụdị atọ dị iche iche nke QC nwalere, naanị galactosylated liposomal QC nyere nchebe dị ukwuu megide mmebi imeju oxidative CCl4 kpatara.Mgbe awa 24 nke ịgba ọgwụ (SC) sel hepatic nke oke achọpụtara na ọ nwere ike ibute mmebi oxidative CCl4 ma na-enyocha ya site na mmụba nke diene conjugated na akpụkpọ anụ imeju.Mmụba okpukpu abụọ na diene conjugated site na ntinye nke CCl4 belatara ruo ọkwa nkịtị site na ọgwụgwọ mbụ nke galactosylated liposomal QC.Carbontetrachloride butere mmebi akpụkpọ ahụ na mkpụrụ ndụ imeju, a na-ekpekwa ya ikpe site na nyocha ọbara nke pathological na anụ ahụ imeju.A tụlere mmebi nke membrane site na ntinye nke CCl4 site na mbelata ọkwa nke plasma membrane (PM) bound enzyme Na +/K+ ATPase ọrụ ma mụbaa ya naanị site na tupu ọgwụgwọ nke galactosylated liposomal QC.Carbontetrachloride butere mbelata dị ukwuu ma na enzymatic na molecular endogenous antioxidant etoju na imeju mkpụrụ ndụ. A na-egbochi ịda mbà n'obi na sistemu antioxidant na mkpụrụ ndụ imeju kpamkpam site na otu dose nke galactosylated lipsosomal QC tupu ọgwụgwọ CCl4.A na-eme atụmatụ iwelite imeju nke QC mgbe awa 2 gachara ntụtụ flavonoid (8.9 micromol/kg arọ ahụ) (ụdị efu ma ọ bụ liposomal) na 85% nke QC injected ka ahụrụ n'ime imeju n'ihe gbasara galactosylated liposomal QC.Ebe ọ bụ na naanị 25% nke ọgwụ ịgba ọgwụ ka achọpụtara n'ime imeju mgbe agbanyere otu ụdị nke QC efu.Carbontetrachloride mekwara ka mgbanwe dị na mmiri nke akpụkpọ ahụ wee nyochaa ya site na mbelata nke micro-viscosity akpụkpọ ahụ.Ọgwụgwọ tupu ọgwụgwọ QC efu arụpụtaghị ihe nchebe megide CCl4 kpatara mmụba na mmiri ime imeju, ebe galactosylated liposomal QC kpalitere nchebe dị ukwuu megide mmụba ahụ.Nsonaazụ nke ọmụmụ a kpughere na QC na liposome galactosylated nwere ike itinye nchebe dị ukwuu megide mmerụ ahụ hepatocellular kpatara CCl4.
