Ngwaahịa

4- (4-Fluorophenyl) -6-isopropyl-2-[(N-methyl-N-methylsulfonyl) amino] pyrimidine-5-yl-methanol, nke a makwaara dị ka Z6, bụ ngwakọta kemịkalụ nwere ngwa nwere ike na mpaghara ọgwụ. .Ọdịdị ya pụrụ iche na otu ndị na-arụ ọrụ na-eme ka ọ bụrụ onye na-adọrọ mmasị maka nchọpụta ọgwụ na mmepe. Otu nwere ike iji Z6 dị ka ihe na-egbochi mkpali.Mbufụt na-ekere òkè n'ọtụtụ ọrịa, gụnyere ọrịa ogbu na nkwonkwo, ọrịa bowel na-egbuke egbuke, na ụkwara ume ọkụ.Z6's fluoro-dochie phenyl group na pyrimidine core na-eme ka ọ dị mma maka imekọrịta ihe na ebumnuche ndị dị iche iche na-etinye aka na usoro mkpali ahụ, nke nwere ike iduga n'ịzụlite ọgwụ mgbochi mkpali ọhụrụ.Z6 na-ejikwa nkwa dị ka onye na-ahụ maka nje.Ọrịa nje na-anọgide na-abụ nnukwu nchegbu ahụike zuru ụwa ọnụ, a na-enwekwa mkpa mgbe nile maka usoro ọgwụgwọ nje ọhụrụ ma dị irè.Ọnụnọ nke otu isopropyl dị na Z6 na-eme ka akụrụngwa hydrophobic ya dịkwuo elu, na-enye ya ohere ịbanye n'ime membranes viral ma gbochie nje virus.Enwere ike ịhazi atụmatụ nhazi ya ka ọ bụrụ kpọmkwem nwapụta enzymes ma ọ bụ protein, na-eduga n'ịmepụta ọgwụ mgbochi dị ike. Na mgbakwunye, Z6 nwere ike ịnwe ngwa na ọgwụgwọ ọrịa cancer.A na-ahụkarị ìgwè phenyl nke nọchiri anya fluoro na isi pyrimidine na ogige ndị nwere ọrụ mgbochi ọrịa kansa.Site n'ịgbanwe usoro Z6, ọ ga-ekwe omume ịmepụta usoro ndị na-ahọrọ mkpụrụ ndụ cancer, na-egbochi uto ha na ịkpalite apoptosis mgbe ha na-echekwa sel ahụike.A pụkwara imeziwanye ihe na-edozi ahụ na nkwụsi ike na-eme ka ọ dịkwuo mma ma belata mmetụta ndị nwere ike ime. Ọzọkwa, a pụrụ iji Z6 mee ihe dị ka mmalite maka njikọ nke obere ọba akwụkwọ molekul ma ọ bụ chemical scaffolds.Ọ na-enye mgbanwe maka mgbanwe na njikarịcha, na-enye ohere maka nyocha nke nhazi-mmekọrịta mmekọrịta na njirimara nke ogige ndu maka mmepe ọzọ. Na nchịkọta, Z6 bụ onyinye na-ekwe nkwa na ngwa nwere ike na mpaghara ọgwụ.Atụmatụ nhazi ya na otu ndị na-arụ ọrụ na-eme ka ọ dị mma maka ọgwụgwọ ọgwụgwọ dị iche iche, gụnyere mgbochi mkpali, ọgwụ nje na ọgwụ mgbochi ọrịa cancer.Site na nyocha na mmepe n'ihu, Z6 na usoro ya na-enwe ike inye aka dị ukwuu na nchọpụta ọgwụ yana inye aka na mmepe nke usoro ọgwụgwọ ọhụrụ na nke dị irè.