Ngwaahịa

(+) - (3R, 5S), tert-Butyl 7-[4- (4-fluorophenyl) -6-isopropyl-2- (N-methyl-N-methylsulphonylamino) -pyrimidin-5-yl] -3,5 -dihydroxy-6 (E) -heptenate, nke a makwaara dị ka R1.5 ma ọ bụ tert-butyl-rosuvastatin, bụ ngwakọta kemịkalụ nwere ike itinye n'ọrụ na ụlọ ọrụ ọgwụ. ọgwụ ndị a na-akpọ statins.Ọ na-arụ ọrụ site na igbochi enzyme a na-akpọ HMG-CoA reductase, nke na-etinye aka na mmepụta nke cholesterol n'ime ahụ.R1.5 bụ ihe mpụta nke rosuvastatin nwere otu tert-butyl nke jikọtara ya na molekul, na-enye ihe ndị ọzọ na uru ndị nwere ike ime. Otu ngwa nke R1.5 nwere ike ịbụ ihe ọgwụ maka ọgwụgwọ hyperlipidemia na mgbochi ọrịa obi.Dị ka rosuvastatin, enwere ike iji R1.5 belata ọkwa LDL cholesterol, nke a makwaara dị ka cholesterol "ọjọọ", yana triglycerides n'ime ọbara.Ngwakọta a nwere ike igosipụta njirimara pharmacokinetic emelitere, dị ka mmụba bioavailability ma ọ bụ nkwụsi ike, ma e jiri ya tụnyere ọgwụ nne na nna.Ọzọkwa, ndị otu tert-butyl nwere ike itinye aka na ngwakọta nke solubility na nhazi nhazi, na-eme ka ọ dị mma maka usoro nnyefe ọgwụ dị iche iche. Ihe ọzọ nwere ike iji R1.5 na-emepụta ihe na-emepụta ọgwụ ma ọ bụ usoro nnyefe ọgwụ ezubere iche.Otu tert-butyl nwere ike rụọ ọrụ dị ka otu nchekwa, na-enye ohere maka mwepụta nke rosuvastatin n'ime anụ ahụ ma ọ bụ akụkụ ahụ akọwapụtara, dị ka imeju.Usoro a nwere ike ime ka ọgwụ ahụ dịkwuo mma ma belata mmetụta ndị nwere ike ime site n'ịba ụba ya na ebe a na-achọsi ike ma na-ebelata ikpughe na anụ ahụ na-abụghị nke ezubere iche. Ọzọkwa, R1.5 nwere ike ịbụ ngwá ọrụ bara uru maka ndị na-ahụ maka ọgwụ na-ahụ maka ọgwụ na nchọpụta na mmepe ọgwụ.Ihe owuwu dị mgbagwoju anya nke ogige ahụ na-enye ikpo okwu maka mgbanwe ndị ọzọ na mwepu.Ndị na-eme nchọpụta nwere ike iji R1.5 dị ka ihe na-edu ndú iji nyochaa nhazi-mmekọrịta ọrụ na ịmepụta ihe atụ ọhụrụ na ike, nhọrọ, ma ọ bụ profaịlụ ọgwụgwọ dị mma.Ọmụmụ ihe dị otú ahụ nwere ike inye aka na mmepe nke statins dị irè ma ọ bụ ndị ọzọ na-ebelata cholesterol. Na njedebe, (+) - (3R, 5S), tert-Butyl 7-[4- (4-fluorophenyl)) -6-isopropyl -2- (N-methyl-N-methylsulphonylamino) -pyrimidin-5-yl] -3,5-dihydroxy-6 (E) -heptenate (R1.5 ma ọ bụ tert-butyl-rosuvastatin) na-ekwe nkwa dị ka ọgwụ ọgwụ maka ọgwụ. ọgwụgwọ hyperlipidemia na ọrịa obi.Ọdịdị ya pụrụ iche, jikọtara ya na otu tert-butyl, nwere ike inye uru dị ka pharmacokinetics emelitere, nnyefe ọgwụ ezubere iche, na ohere maka mmepe ọgwụ ọzọ.Achọkwu nyocha na mmepe iji chọpụta nke ọma ikike R1.5 na mpaghara ọgwụ.