Ngwaahịa

Acetoxy Empagliflozin, nke a makwaara dị ka empagliflozin acetate, bụ ụdị empagliflozin nke ọgwụ antidiabetic emezigharịrị.Empagliflozin so na otu ọgwụ akpọrọ sodium-glucose co-transporter 2 (SGLT2) inhibitors, nke a na-ejikarị eme ihe maka njikwa ụdị ọrịa shuga mellitus nke 2.Site na igbochi protein a, (3R,4S,5R,6R) -3,4,5-tris (triMethylsilyloxy) -6-((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu bụ ngwakọta kemịkalụ dị mgbagwoju anya nwere ogologo aha kemikal.Ọ na-adaba n'okpuru klas nke triMethylsilyloxy pyranones, nke a na-ejikarị eme ihe na nkà mmụta sayensị na ụlọ ọrụ mmepụta ihe dị iche iche. Otu n'ime ihe dị mkpa eji eme ihe (3R,4S,5R,6R) -3,4,5-tris(triMethylsilyloxy) -6- ( (triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu bụ otu na-echebe na organic njikọ.Otu nchekwa bụ otu na-arụ ọrụ nwa oge nke a na-eji echekwa saịtị ndị na-emeghachi omume na molekul n'oge mmeghachi omume kemịkal.N'ihe banyere (3R,4S,5R,6R) -3,4,5-tris (triMethylsilyloxy) -6- ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu, ndị otu triMethylsilyloxy na-arụ ọrụ dị ka ihe nchebe. .N'oge mmeghachi omume, otu ndị a na-echebe ụfọdụ ndị na-arụ ọrụ ka ha ghara inwe mmeghachi omume na-achọghị, na-ekwe ka mmeghachi omume ha na-aga n'ihu nke ọma.Mgbe mmeghachi omume ahụ mechara, enwere ike iwepụ ndị otu triMethylsilyloxy ngwa ngwa, na-ekpughe otu ọrụ mbụ na-arụ ọrụ. Ojiji ọzọ nke (3R,4S,5R,6R) -3,4,5-tris (triMethylsilyloxy) -6- ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu bụ na njikọ nke organic ogige.Enwere ike iji ya rụọ ọrụ dịka ngọngọ ụlọ iji wuo ihe owuwu dị mgbagwoju anya.Njirimara kemịkalụ ya pụrụ iche na mmeghachi omume na-eme ka ọ bụrụ ngwá ọrụ bara uru na mmepe nke ụlọ ọrụ kemịkal ọhụrụ.Ndị na-ahụ maka ọgwụ nwere ike iji (3R,4S,5R,6R) -3,4,5-tris (triMethylsilyloxy) -6- ((triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu iji webata otu ndị na-arụ ọrụ dị iche iche ma ọ bụ mepụta molekụla akọwapụtara. scaffolds iji mụọ ọrụ ndu nke ogige ma ọ bụ mepụta ọgwụ ọhụrụ. Tụkwasị na nke a, ogige a nwere ike ịchọta ngwa n'ọhịa nke sayensị ihe onwunwe.Ọnụnọ ya dị ka otu na-arụ ọrụ na molekul nwere ike inye ụfọdụ ihe ndị a na-achọsi ike na ihe.Dịka ọmụmaatụ, ọ nwere ike ịkwalite solubility na ụfọdụ ihe mgbaze ma ọ bụ melite ihe ndị na-emepụta ihe nkiri, na-eme ka ọ baa uru na mkpuchi ma ọ bụ adhesives.(3R,4S,5R,6R) -3,4,5-tris (triMethylsilyloxy) -6-( triMethylsilyloxy) Methyl) tetrahydro-2H-pyran-2-otu bụ a ukwuu pụrụ iche ogige na vasatail ojiji dị iche iche na sayensị na ulo oru mbo.Ikike ya ime ihe dị ka otu nchebe ma na-eje ozi dị ka ihe owuwu ụlọ na kemịkalụ sịntetik, yana ngwa ndị nwere ike ime na sayensị ihe onwunwe, na-eme ka ọ bụrụ akụkụ bara uru na mmepe nke mkpụrụ ndụ ọhụrụ na ihe ọhụrụ.Agbanyeghị, ngwa ya na ojiji ya nwere ike ịdịgasị iche, dabere na ihe achọrọ na ebumnuche nke otu ọrụ sayensị ma ọ bụ ụlọ ọrụ mmepụta ihe.