Ngwaahịa

(3R,4R) -1- (tert-Butoxycarbonyl) -4-methylpyrrolidine-3-carboxylic acid, nke a makwaara dị ka Boc-4-methylproline, bụ ngwakọta kemịkalụ nke a na-ejikarị eme ihe n'ọhịa nke njikọ organic, karịsịa na mmepụta nke peptides na peptidomimetics maka ngwa dị iche iche. Otu n'ime isi ojiji nke Boc-4-methylproline bụ otu nchebe maka amino acid nke amino acid n'oge njikọ peptide.Otu nchekwa bụ mgbanwe nwa oge nke na-echebe otu ụmụ irighiri ihe na-arụ ọrụ nke ọma iji gbochie mmeghachi omume na-achọghị n'oge usoro sịntetik.Na njikọ peptide, Boc-4-methylproline na-arụ ọrụ dị ka otu nchekwa maka otu amine, na-enye ohere maka ntinye nhọrọ nke amino acid ndị ọzọ ka ọ mepụta usoro peptide chọrọ. njikọ nke ogige dị iche iche nwere ihe omume ndu.Dị ka ngwakọta chiral, ọ nwere stereocenter, na-eme ka entiomers abụọ pụta: (3R,4R) -Boc-4-methylproline na (3S, 4S) -Boc-4-methylproline.Onye ọ bụla enantiomer nwere ike igosipụta akụrụngwa ọgwụ dị iche iche yana mmekọrịta yana ebumnuche ndu.Site n'iji Boc-4-methylproline mee ihe dị ka ihe mmalite, ndị na-ahụ maka ọgwụ nwere ike ịnweta ọtụtụ ogige chiral maka nchọpụta ọgwụ na mmepe. Ọzọkwa, Boc-4-methylproline ihe ndị na-emepụta ihe egosipụtawo ọrụ antimicrobial, antiviral, na anticancer.A na-enyocha ogige ndị a maka ikike ha dị ka ọgwụgwọ ọgwụgwọ megide nje dị iche iche, gụnyere nje bacteria, nje na mkpụrụ ndụ cancer.Site n'ịgbanwe usoro nke Boc-4-methylproline na nyochaa usoro ya, ndị nchọpụta nwere ike nyochaa ikike ha dị ka ogige ndu ma ọ bụ ihe ndị na-emepụta ihe maka ịmepụta ọgwụ. na mmepụta nke peptidomimetics.Peptidomimetics bụ ogige na-eṅomi nhazi na ọrụ nke peptides mana nwere nkwụsi ike na akụrụngwa ọgwụ.Boc-4-methylproline nwere ike ịrụ ọrụ dị ka ihe mgbochi ụlọ na nhazi na njikọ nke peptidomimetics, na-enye ohere maka mmepe nke usoro ọgwụgwọ ọhụrụ na bioavailability dị mma na nke ezubere iche.Na nchịkọta, (3R,4R) -1- (tert-Butoxycarbonyl) - 4-methylpyrrolidine-3-carboxylic acid, ma ọ bụ Boc-4-methylproline, bụ ngwakọta nke a na-ejikarị eme ihe na njikọ organic.Ọrụ ya dị ka otu nchebe na peptide synthesis, nakwa dị ka chiral ya, na-eme ka ọ bụrụ ihe dị oké ọnụ ahịa maka ịmepụta peptides, peptidomimetics, na ogige chiral.A na-enyocha ihe ndị sitere na Boc-4-methylproline maka ọrụ ndụ ha nwere ike ime, nke gụnyere antimicrobial, antiviral, na anticancer.Nnyocha na ihe ọhụrụ na-aga n'ihu na iji Boc-4-methylproline na-emepụta ọgwụ na-enye aka na mmepe nke ndị na-ahụ maka ọgwụgwọ ọhụrụ na imeziwanye nghọta anyị nke usoro ndu mgbagwoju anya.