Ngwaahịa

(3aR,7aR) -4- (benzo [d] isothiazol-3-yl) octahydrospiro [isoindole-2,1-piperazin] -2-ium4-methylbenzenesulfonate, nke a na-akpọkwa BISO, bụ ngwakọta kemịkalụ nwere Ọdịdị pụrụ iche nke na-agbazinye onwe ya n'ọtụtụ ihe nwere ike ime n'ọhịa nke ọgwụ kemịkalụ na mmepe ọgwụ.Otu ngwa BSO nwere ike ime bụ ọgwụgwọ ọrịa akwara ozi.Ọnụnọ nke benzo [d] isothiazol-3-yl moiety na nhazi ya na-egosi na BSO nwere ike inwe mmekọrịta na usoro neurotransmitter kpọmkwem na ụbụrụ, dị ka glutamate ma ọ bụ GABAergic usoro.Usoro neurotransmitter ndị a na-etinye aka na ọtụtụ nsogbu akwara ozi dị ka Akwụkwụ na-adọ, nchekasị, na nsogbu ọnọdụ ọnọdụ.Ndị na-eme nchọpụta nwere ike ịchọpụta ikike BISO nwere iji gbanwee usoro ndị a ma mepụta ihe ọhụrụ ọgwụgwọ ọgwụgwọ maka ọnọdụ akwara ozi. Ọzọkwa, BISO's spiro [isoindole-2,1-piperazin] isi nhazi nwere ike iji mee ihe na mmepe nke ọgwụ ndị na-elekwasị anya n'ọtụtụ dịgasị iche iche. ebumnuche ndu.Ụdị akụkụ atọ ya na ọnụnọ nke otu ndị na-arụ ọrụ nwere ike imekọrịta ihe na ndị na-anabata ya ma ọ bụ enzymes kpọmkwem, na-enye ohere maka ịmepụta ọgwụ ndị na-ahọrọ na ndị nwere ike.Ndị na-eme nchọpụta nwere ike ịkwado ebumnuche a iji mepụta obere ụmụ irighiri ihe na-elekwasị anya na ndị na-anabata ya na-etinye aka na ọrịa dị iche iche, dị ka ọrịa cancer, ọrịa obi, ma ọ bụ ọrịa na-efe efe. Ọzọkwa, BIS's spirocyclic structure na ebubo ammonium otu na-eme ka ọ bụrụ onye nwere ike ịkwado usoro nnyefe ọgwụ.Ọnụnọ nke otu ebubo na-enye ohere maka ịmepụta ogige ionic na ụmụ irighiri ihe na-adịghị mma, dị ka acid nucleic ma ọ bụ protein.Ihe mgbagwoju anya ndị a nwere ike ịkwado nnyefe ezubere iche nke mkpụrụ ndụ bioactive n'ime mkpụrụ ndụ ma ọ bụ anụ ahụ kpọmkwem, na-eme ka ọgwụgwọ ọgwụgwọ dịkwuo mma ma na-ebelata mmetụta nke usoro.Ọdịdị ya pụrụ iche na-enye ohere maka ndị na-ahụ maka ọgwụ na-ahụ maka ọgwụ iji nyochaa akụrụngwa ọgwụ ya na ịkwalite ikike ya maka nchọpụta ọgwụ. Dị ka ọ dị na ngwakọta kemịkalụ ọ bụla, iji BISO kwesịrị ịgbaso ụkpụrụ nchekwa na ụkpụrụ nduzi.Ndị na-eme nchọpụta kwesịrị ịkpachara anya n'oge nhazi ya, njikwa ya, na nchekwa ya iji hụ na nchekwa ma belata ihe ize ndụ. N'ikpeazụ, (3aR,7aR) -4- (benzo [d] isothiazol-3-yl) octahydrospiro [isoindole-2,1-piperazin ] -2-ium4-methylbenzenesulfonate, ma ọ bụ BISO, na-ekwe nkwa maka ngwa dị iche iche na kemistri ọgwụ na mmepe ọgwụ.Ọdịdị ya pụrụ iche na-enye ohere maka nchọpụta ọgwụgwọ ọhụrụ, usoro nnyefe ọgwụ ezubere iche, na mgbanwe nke usoro neurotransmitter.Agbanyeghị, nyocha dị ukwuu dị mkpa iji kọwapụta ikike ya n'ụzọ zuru oke wee bulie ojiji ya na ngalaba ọgwụ.