Ngwaahịa

Ricin toxin (RT) bụ nsi nke abụọ kacha egbu egbu mara;CDC ahọpụtala ya dị ka onye nnọchi anya ahọpụtara.A na-eme RT site na osisi castor bean;A na-emepụta ihe dị ka tọn 50,000 nke RT kwa afọ dị ka ihe sitere na mmanụ castor.RT nwere akụkụ abụọ, a yinye ribotoxic A (RTA) na galactose-binding B chain (RTB).RT na-ejikọta na sel niile mammalian na ozugbo etinyere ya, otu RTA na-eme ka ribosomes niile dị na cell rụọ ọrụ.A na-elekọta ya dị ka ikuku ikuku, RT na-ebute mmebi ngụgụ ngwa ngwa yana fibrosis na-esote ọnwụ.Enweghị ọgwụ mgbochi nri na ọgwụ nchịkwa kwadoro yana ọgwụgwọ na-adị irè naanị n'ime awa ole na ole mbụ mgbe ekpughere ya.Anyị ewepụtala ọgwụ mgbochi RTA recombinant nwere mmụgharị abụọ V76M/Y80A (RiVax).A na-egosipụta protein ahụ na Escherichia coli na ọ naghị egbu egbu yana immunogenic na ụmụ oke, oke bekee na ụmụ mmadụ.Mgbe a na-ama ụmụ oke ịgba ọgwụ mgbochi ọrịa ịgbanye, ikuku ikuku, ma ọ bụ ọnụ ọnụ (gavaged) RT, a na-echebe ha kpamkpam.Ugbu a, anyị ewepụtala usoro nke RiVax nwere thermostable, aluminom ma nwalee ya na rhesus macaques.Mgbe ịgbanye ọgwụ mgbochi atọ, ụmụ anụmanụ ahụ mepụtara ọgwụ mgbochi ọrịa nke chebere ha kpam kpam pụọ na ọgwụ na-egbu egbu nke aerosolized RT.Ọgwụ mgbochi ndị a wepụrụ RT wee zọọ ọkwa dị iche iche site na otu panel nke mgbochi mgbochi na mgbochi na-adịghị ahụ maka mgbochi monoclonal òké mara amara na-amata ụfọdụ epitopes na RTA ala ala.Profaịlụ asọmpi mgbochi mmadụ ga-esi na ya pụta nwere ike ịnọchite anya mbinye aka nchebe nke immunologic.N'ụzọ dị mkpa, a hụrụ otu mbinye aka ahụ site na iji sera sitere na RiVax ụmụ mmadụ gbara ọgwụ mgbochi.