Ngwaahịa

3-tert-Butoxycarbonylphenylboronic acid, makwaara dị ka Boc-phenylboronic acid, bụ ihe dị mkpa boronic acid ewepụtara na ịrịba ngwa na organic njikọ na ọgwụ kemịkalụ.One nke isi ojiji nke 3-tert-butoxycarbonylphenylboronic acid bụ dị ka a ichebe otu na organic. njikọ.A na-ejikarị otu tert-butyloxycarbonyl (BOC) na-arụ ọrụ iji chebe otu ọrụ amine nwa oge n'oge mmeghachi omume dị iche iche.Site na ijikọ otu BOC na akụkụ amine, a na-ebelata mmeghachi omume nke amine, na-enye ohere maka mmeghachi omume nhọrọ na ọnọdụ ndị ọzọ na molekul.Enwere ike iwepụ otu BOC ngwa ngwa n'okpuru ọnọdụ dị nro, si otú a na-egosipụta ọrụ amine mbụ.Atụmatụ otu nchekwa a na-enyere aka njikọ nke ọma nke ụmụ irighiri ihe ndị dị mgbagwoju anya, dị ka ọgwụ na ngwaahịa sitere n'okike. Ọzọkwa, 3-tert-Butoxycarbonylphenylboronic acid na-eje ozi dị ka reagent bara uru maka ịmepụta njikọ carbon-carbon.Acids Boronic, gụnyere Boc-phenylboronic acid, na-etolite esters boronate ngwa ngwa mgbe ejiri nucleophiles meghachi omume, dị ka alcohols ma ọ bụ amines.Ndị esters boronate ndị a nwere ike ịme mgbanwe dị iche iche, gụnyere mmeghachi omume njikọta nke Suzuki-Miyaura, njikọta Negishi, na njikọta Stille.Mmeghachi omume ndị a na-enyere aka guzobe ụmụ irighiri ihe dị mgbagwoju anya nwere usoro nnọchi dị iche iche na otu ọrụ.Boc-phenylboronic acid bara uru karịsịa maka iwebata moiety phenylboronic acid n'ime ụmụ irighiri ihe e lekwasịrị anya. Na mgbakwunye, boc-phenylboronic acid na-arụ ọrụ dị oke mkpa na kemistri ọgwụ.Ọrụ boronic acid nwere ike ịhọrọ nke ọma ka ya na diols ma ọ bụ boronate ester-sensitive dị iche iche na-arụ ọrụ na ebumnuche ndu, na-eme ka imepụta ihe mgbochi enzyme boronate dabere na ligands nnabata.Enwere ike itinye boc-phenylboronic acid n'ime obere ihe mgbochi molecule, peptides, ma ọ bụ prodrugs iji nye akụrụngwa achọrọ ma ọ bụ welie ebumnuche ebumnuche.Ogige ndị a na-adabere na boronate egosila nkwa na ọgwụgwọ ọrịa dị iche iche, gụnyere ọrịa cancer, ọrịa shuga, na mbufụt. Na nchịkọta, 3-tert-Butoxycarbonylphenylboronic acid, ma ọ bụ Boc-phenylboronic acid, na-achọta ngwa dị iche iche na nchịkọta organic na ọgwụ ọgwụ.Otu BOC ya na-eje ozi dị ka otu nchekwa, na-enye ohere maka mmeghachi omume nhọrọ na ọnọdụ ndị ọzọ na molekul.Ọzọkwa, ọrụ boronic acid na-enyere aka imepụta carbon-carbon bond, na-eme ka njikọ nke ụmụ irighiri ihe dị mgbagwoju anya.Na mgbakwunye, Boc-phenylboronic acid na-arụ ọrụ dị mkpa na kemịkalụ ọgwụ, ebe a na-eji ya na imepụta ihe inhibitors enzyme boronate na ligands nnabata.N'ozuzu, Boc-phenylboronic acid bụ reagent bara uru nke na-enye aka na ọganihu na kemịkalụ sịntetik na nchọpụta nchọpụta ọgwụ.