Ngwaahịa

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone, nke a na-akpọkarị TMS-D-glucose, bụ ngwakọta dị iche iche nke na-achọta ngwa na mpaghara sayensị dị iche iche, gụnyere njikọ organic, kemịkalụ carbohydrate, na kemịka nyocha. TMS-D-glucose bara uru karịsịa na njikọ organic ka ọ na-eje ozi dị ka otu nchebe maka otu ọrụ hydroxyl (OH) na carbohydrates.Site na iwebata ndị otu trimethylsilyl (TMS) n'ime ìgwè hydroxyl nke glucose, ihe mejupụtara ahụ na-adịkwu mma ma na-emeghachi omume, na-enye ohere maka mgbanwe nhọrọ nke otu hydroxyl dị iche iche ma na-ahapụ ndị ọzọ na-enweghị mmetụta n'oge mgbanwe kemịkalụ na-esote.A na-eji usoro nchebe nchebe a nke ọma na kemistri carbohydrate iji nweta regioselectivity na stereochemistry chọrọ na njikọ nke carbohydrates dị mgbagwoju anya, glycoconjugates, na ngwaahịa ndị sitere n'okike. nke carbohydrates.Site n'ịtụgharị carbohydrates n'ime usoro trimethylsilyl ha, mgbanwe ha na nkwụsi ike nke okpomọkụ na-akawanye mma, na-eme ka ha dị mma maka nyocha nke gas chromatography (GC) na mass spectrometry (MS).Nke a derivatization Usoro enhances nchọpụta uche, mma nkewa arụmọrụ, na-enyere njirimara nke dị iche iche carbohydrates na mgbagwoju ngwakọta, dị ka ndu samples ma ọ bụ nri ngwaahịa.TMS-D-glucose na-ahụkwa ngwa na njikọ nke pụrụ iche reagents na chemical nyocha.Mmeghachi omume pụrụ iche na nkwụsi ike ya na-eme ka ọ bụrụ ihe mmalite bara uru maka nkwadebe nke ogige ndị ọzọ sitere na carbohydrate.Ndị na-eme nchọpụta nwere ike gbanwee moiety trimethylsilyl ma ọ bụ dochie moiety glucose iji mepụta ogige nwere ihe ndị a kapịrị ọnụ, dị ka nyocha fluorescent, enzyme inhibitors, ma ọ bụ ndị na-achọ ọgwụ.Enwere ike iji usoro ndị a rụọ ọrụ na ọmụmụ ihe ọmụmụ dị iche iche nke ndụ na biomedical, gụnyere imaging, mmepe ọgwụ, ma ọ bụ ịghọta mmekọrịta protein-protein. mkpachapụ anya.Ndị na-eme nchọpụta ga-ahụrịrị na ikuku ikuku zuru oke ma jiri akụrụngwa nchedo onwe onye kwesịrị ekwesị mgbe ha na-arụ ọrụ na ogige a iji gbochie ihe ize ndụ ahụike.Na mgbakwunye, dị ka ọ dị na reagent ọ bụla, ịdị ọcha, na ịdịmma nke TMS-D-glucose dị oke mkpa iji nweta nsonaazụ a pụrụ ịdabere na ya na nke enwere ike imepụtaghachi.Na nchịkọta, TMS-D-glucose bụ onyinye bara uru na njikọ organic, kemịkalụ carbohydrate, na kemịka nyocha.Ikike ya ichebe otu hydroxyl n'ime carbohydrates, ntinye ya na nyocha carbohydrate, yana ịba uru ya na njikọ nke reagents pụrụ iche na-eme ka ọ bụrụ ngwa dị mkpa na usoro sayensị dị iche iche.Site na iji TMS-D-glucose, ndị na-eme nchọpụta nwere ike ịga n'ihu na ọmụmụ ha na kemịkalụ carbohydrate, glycoscience, na mpaghara ndị metụtara ya, na-enye aka na mmepe nke ogige ọhụrụ, nchọpụta nchọpụta, na ndị na-agwọ ọrịa.