Ngwaahịa

(1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane-2-carboxylic acid Methyl ester hydrochloride bụ ngwakọta kemịkalụ nwere ngwa dị iche iche na nyocha ọgwụ na mmepe ọgwụ. isi ojiji nke onyinye a dị ka ihe mgbochi ụlọ chiral na njikọ nke ndị na-ahụ maka ọgwụ na ihe ndị na-emepụta ọgwụ na-arụ ọrụ (APIs).Ọdịdị igwe kwụ otu ebe pụrụ iche na chirality na-eme ka ọ baa uru na mmepụta nke ogige dị ọcha.Site n'itinye onyinye a n'ime njikọ ahụ, ndị na-ahụ maka chemist nwere ike ijikwa stereochemistry ma mepụta kpọmkwem ọgwụ ọgwụ na ụmụ irighiri ihe ndị na-esi na ya pụta.Nke a dị mkpa karịsịa na mmepe ọgwụ, ebe ihe omume ndụ chọrọ na-adaberekarị na nhazi oghere nke molecule. Ọzọkwa, (1R,2S,5S) -6,6-DiMethyl-3-aza-bicylo[3.1.0] hexane -2-carboxylic acid Methyl ester hydrochloride na-eji dị ka ihe mmalite maka njikọ nke ọgwụ ndị dabeere na quinuclidine.Mwepụta nke Quinuclidine egosila ọtụtụ ihe omume ndu, gụnyere antipsychotic, anticonvulsant, na analgesic Njirimara.Site n'iwebata otu ndị na-arụ ọrụ dị iche iche na ogige ahụ, ndị na-ahụ maka ọgwụ nwere ike gbanwee pharmacokinetic na pharmacodynamic Njirimara, na-eme ka ikike ọgwụgwọ ya dịkwuo mma. Ọzọkwa, ihe a na-ahụta na-eji ya dị ka onye na-emeghachi omume ma ọ bụ ihe na-eme ka ọ bụrụ ihe na-eme mgbanwe na organic.N'ihi ọnụnọ nke amine tertiary na ọdịdị mgbochi siri ike nke otu methyl, ọ nwere ike isonye na mmeghachi omume kemịkalụ dị iche iche, dị ka amidation, alkylation, na mmeghachi omume cycloaddition.Mmeghachi omume ya na ikike ịmepụta etiti etiti dị mgbagwoju anya na-eme ka ọ bụrụ ngwá ọrụ dị iche iche na nhazi nke organic, na-enye ohere ịmepụta ogige dị iche iche dị iche iche. Na nchịkọta, (1R,2S,5S) -6,6-DiMethyl-3-aza-bicylo[3.1] .0]hexane-2-carboxylic acid Methyl ester hydrochloride bụ ihe bara uru na mmepe ọgwụ na njikọ organic.Chirality ya na nhazi ya pụrụ iche na-enyere aka ịmepụta ogige enantiomerically dị ọcha yana njikọ nke ọgwụ ndị dabeere na quinuclidine nwere ihe ndị na-emepụta ọgwụ.Nmeghachi omume ya na-emekwa ka ọ bụrụ ihe na-emeghachi omume bara uru ma na-akpalite mgbanwe kemịkalụ dị iche iche.N'ozuzu, ogige a na-ekere òkè dị ukwuu na ọganihu nke nyocha ọgwụ na mmepe nke ndị na-ahụ maka ọgwụgwọ ọhụrụ.