Ngwaahịa

1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine -3-carboxylic acid ethyl ester bụ ngwakọta kemịkalụ dị mgbagwoju anya nke gosipụtara ikike n'akụkụ dị iche iche nke kemistri ọgwụ na nchọpụta ọgwụ.Nke a bụ nkọwa nke ojiji ya n'ihe dị ka okwu 300. Ngwakọta a, nke a na-akpọkarị ethyl ester derivative nke 1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-yl). phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c] pyridine-3-carboxylic acid, bụ nke klas nke pyrazolo[3,4-c] pyridine.Mwepụta ndị a adọtara uche na nchọpụta ọgwụ n'ihi ikike ha nwere na mpaghara ọgwụgwọ dị iche iche. Otu ngwa nwere ike ime nke a bụ n'ọhịa nke nchọpụta ọrịa cancer.Pyrazolo [3,4-c] pyridine ewepụtara egosipụtala ọrụ mgbochi proliferative na-ekwe nkwa megide ọtụtụ ụdị mkpụrụ ndụ kansa.Ikike ha igbochi ụzọ a kapịrị ọnụ na-etinye aka na uto tumor na ịdị ndụ na-eme ka ha bụrụ ndị nwere ike ime ka ha mepụta ọgwụ mgbochi ọrịa cancer.Ọmụmụ ihe ndị ọzọ dị mkpa iji chọpụta usoro nke ime ihe ma nyochaa irè nke ogige ahụ na nhazi nke mbụ na ụlọ ọgwụ. Ọzọkwa, ogige a egosila nkwa dị ka onye na-ahụ maka nje bacteria nwere ike.Ọ egosipụtala ọrụ megide ụdị nje bacteria dị iche iche, gụnyere ma nje bacteria gram-positive na gram-negative.Ikike ịchebe ọtụtụ ụdị dị iche iche na-egosi ikike ọ nwere n'ịlụso nje bacteria na-eguzogide ọgwụ ọgụ, bụ ndị ghọworo nnukwu nchegbu ahụike zuru ụwa ọnụ.A na-akwado nyocha ọzọ iji nyochaa ụdị omume ya ma chọpụta irè ya n'ịlụso ọrịa nje ọgụ. Ọzọkwa, ihe ndị na-emepụta pyrazolo [3,4-c] pyridine, gụnyere ogige a, egosipụtawo ike na ọgwụgwọ nke ọrịa na-egbuke egbuke na autoimmune.Mbufụt na-arụ ọrụ dị oke egwu na ọnọdụ dị iche iche dịka ọrịa ogbu na nkwonkwo na psoriasis.Mwepụta ndị a egosipụtala ihe mgbochi mkpali site n'ịgbanwe ụzọ a kapịrị ọnụ na-etinye aka na nzaghachi mkpali.Nke a na-egosi ikike ha dị ka ndị na-agwọ ọrịa maka ijikwa ọkụ na-adịghị ala ala na ọrịa ndị metụtara ya. Ọzọkwa, onyinye a egosila ọrụ na usoro nhụjuanya nke etiti (CNS).Achọpụtala ya maka ikike ọ nwere na nsogbu akwara ozi dị ka ọrịa Alzheimer na ọrịa Parkinson.Ngwakọta ahụ nwere ike gbanwee ndị na-anabata ya na enzymes na-etinye aka na ọganihu ọrịa, nwere ike inye mmetụta neuroprotective.Otú ọ dị, a chọrọ nyocha ọzọ iji ghọta nke ọma usoro ọrụ ya ma chọpụta na ọ dị irè n'ịgwọ ọrịa ndị a dị mgbagwoju anya. Na nchịkọta, 1- (4-Methoxyphenyl) -7-oxo-6-[4- (2-oxopiperidin-1-) yl) phenyl] -4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c] pyridine-3-carboxylic acid ethyl ester na-ekwe nkwa n'ọtụtụ ebe ọgwụgwọ, gụnyere mgbochi cancer, antibacterial, mgbochi mkpali. , na ọrịa CNS.Ike ya dabere n'ikike ya ịchebe ụzọ a kapịrị ọnụ yana ndị nnabata na-etinye aka na ọnọdụ ndị a.Agbanyeghị, nyocha na nyocha ọzọ dị mkpa iji chọpụta nke ọma ikike ya, bulie akụrụngwa ya, wee chọpụta nchekwa ya na nrụpụta ya na ntọala ụlọ ọgwụ.